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Author:   Hippokratis Kiaris
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Wiley-VCH Verlag GmbH
Dimensions:   Width: 18.40cm , Height: 1.50cm , Length: 24.30cm
Weight:   0.472kg
ISBN:  

9783527314867

ISBN 10:   3527314865
Pages:   188
Publication Date:   16 June 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Foreword. Preface. Part I Basic Aspects. 1 Some Introductory Concepts in Tumor Biology: Clonal Evolution and Autonomy versus Non-autonomy of Cancer Cells. 2 The Cell's Life and Death: Cell Cycle, Senescence and Apoptosis. Part II Genes Involved in Carcinogenesis. 3 Oncogenes. 4 Tumor-suppressor Genes. 5 Genomic Instability. 6 ATwist in the (Genetic) Tail: Cancer Epigenetics. 7 Nonautonomous Interactions in Carcinogenesis: Role of the Tumor Stroma. 8 Telomerase and Cellular Immortality. 9 Tumor Angiogenesis. 10 Metastasis. Part III Specific Topics. 11 Tissue Context as a Determinant of the Tumor-suppressive or Oncogenic Function of Certain Genes. 12 Cancer Stem Cells. 13 Determination of Therapeutic Efficacy - Pharmacogenomics. 14 Certain Chemicals Induce Cancer: Chemical Carcinogenesis. 15 Hormones and Cancer. 16 Viral Oncogenesis. Part IV Unifying the Concepts. 17 Cooperation of Multiple Biological Processes is Needed for the Development of Fully Fledged Malignancy. 18 Carcinogenesis In Vivo: Animal Models and Basic Approaches to Generate Genetically Modified Animals. 19 Multistage Carcinogenesis in Humans: Molecular Epidemiology and the Colon Cancer Model. Part V Future Perspectives. 20 Epilogue. Index.

Reviews

...a valuable read... (Doody's Health Services) ...an indispensable resource for all healthcare professionals involved in cancer research. (Electric Review, February/March 2007)

Author Information

Hippokratis Kiaris studied biology at the University of Athens. After graduate studies at the National Hellenic Research Foundation, Athens, and the Medical School, University of Crete, he joined the Molecular Genetics and Oncology Group at the University of Liverpool. From 1998 to 2000 he was appointed research instructor at Tulane University Medical School in the group of Nobel Laureate Andrew Schally. In 2000 he took up a position at the MGH Cancer Center, Harvard Medical School, before returning to the University of Athens in 2002. His current research focuses on the elucidation of the molecular events that contribute to breast cancer development, and to the mechanistic aspects of tumor-stroma interactions.

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