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Author:   Edward A. Dennis ,  Ralph A. Bradshaw
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 21.60cm , Height: 2.80cm , Length: 27.60cm
Weight:   1.740kg
ISBN:  

9780123838629

ISBN 10:   0123838622
Pages:   610
Publication Date:   04 April 2011
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Volume two includes 183 chapters divided in 8 sections, including: Section A: Protein Phosphorylation 56 Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases 57 Modular Protein Interaction Domains in Cellular Communication 58 Structures of Serine/Threonine and Tyrosine Kinases 59 Protein Tyrosine Kinase Receptor Signaling Overview 60 Signaling by the Platelet-Derived Growth Factor Receptor Family 61 The Epidermal Growth Factor Receptor Family 62 Mechanisms and Functions of Eph Receptor Signaling 63 Cytokine Receptor Signaling 64 The Negative Regulation of JAK/STAT signaling 65 Protein Kinase Inhibitors 66 Integrin Signaling: Cell Migration, Proliferation, and Survival 67 Downstream Signaling Pathways: Modular Interactions 68 Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function 69 Receptor Tyrosine Kinase Signaling and Ubiquitination 70 TGFb Signal Transduction 71 Mitogen-Activated Protein Kinases 72 Recognition of Phospho-Serine/Threonine Phosphorylated Proteins 73 AMP-Activated Protein Kinase 74 Principles of Kinase Regulation 75 Calcium/Calmodulin-Dependent Protein Kinase II 76 Glycogen Synthase Kinase 3 77 The PIKK Family of Protein Kinases 78 Histidine Kinases in Two-Component Signaling Pathways 79 The EF2K/MHCK/TRPM7 Family of Atypical Protein Kinases 80 The Leucine-Rich Repeat Receptor Protein Kinases of Arabidopsis thaliana 81 Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors 82 Clinical Applications of Kinase Inhibitors in Solid Tumors 83 Ubiquitin-Mediated Regulation of Protein Kinases in NFκB Signaling 84 Global Analysis of Phosphoregulatory Networks Section B: Protein Dephosphorylation 85 Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins 86 The Structure and Topology of Protein Serine/Threonine Phosphatases 87 Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases 88 Protein Phosphatase 1 Binding Proteins 89 Protein Serine/Threonine Phosphatase Inhibitors and Human Disease 90 Calcineurin 91 Protein Serine/Threonine-Phosphatase 2C (PP2C) 92 Approaches to the Identification of Protein Tyrosine Phosphatase Substrates 93 Inhibitors of Protein Tyrosine Phosphatases 94 Regulating Receptor PTP Activity 95 CD45

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Author Information

Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research. Ralph A. Bradshaw is Professor of Chemistry and Pharmaceutical Chemistry; and Deputy Director, Mass Spectrometry Facility, University of California, San Francisco, as well as Professor Emeritus, Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, Irvine, CA. He is also Editor of the journal Molecular Cellular Proteomics

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