Overview

Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. Early research focused on the measurement of concentrations, synthesis, and metabolism of 5-HT, and only recently has the focus shifted to characterization of 5-HT receptors. Gaddum and Picarelli first sug­ gested in 1957 that the effect of 5-HT in the guinea pig ileum is mediated by two pharmacologically distinguishable receptors; however, the possibility of dual5-HT receptors was not explored systematically or successfully until the past decade. It is now clear that more, perhaps many more, subclasses of 5-HT receptors exist. The purpose of this book is to provide an up-to-date report on 5-HT receptors. This is a difficult task considering the astonishing speed at which research in this field is expanding. As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT. For those of us who have been work­ ing on 5-HT for many years, our dream of equal progress and recognition with the more extensively studied catecholamines is finally being realized. We now have a Serotonin Club that held its first international scientific meeting in 1987, and several more international meetings are in the planning stages.

Full Product Details

Author:   Elaine Sanders-Bush
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1988 ed.
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   1.650kg
ISBN:  

9780896031425

ISBN 10:   089603142
Pages:   388
Publication Date:   03 February 1989
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Section 1: Historical Perspective.- 1 Historical Perspectives.- Section 2: Characterization of Serotonin Receptor Binding Sites.- 2 Biochemistry and Pharmacology of the 5-HT1 Serotonin Binding Sites.- 3 Pharmacology and Biochemistry of the 5-HT2 Receptor.- 4 Autoradiographic Studies of Serotonin Receptors.- Section 3: Biochemical Mechanisms of Receptor Action.- 5 5-HT Receptors Coupled to Adenylate Cyclase.- 6 5-HT Receptors Coupled to Phosphoinositide Hydrolysis.- Section 4: Correlation of Binding Sites with Function.- 7 Autoreceptors Regulating Serotonin Release.- 8 Electrophysiology of Central Serotonin Receptor Subtypes.- 9 Behavioral Models of Serotonin Receptor Activation.- 10 Serotonin Receptors in Vascular Smooth Muscle.- Section 5: Regulation of Serotonin Receptors.- 11 Regulation of Serotonin Receptors and Responsiveness in the Brain.- Section 6: Future Vistas.- 12 Future Vistas.

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