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OverviewA tribute to the pioneering scientific work of Professor Koji Nakanishi, whose studies of natural products have effaced some of the conventional boundaries between biology and chemistry. It discusses an array of chromatographic separation methods and determination of structures on a microscale, analyzes bioassay-directed fractionation and other means of isolating biologically active compounds from plants and other sources, covers vital enzymes isolated from marine organisms such as algae, and more. Full Product DetailsAuthor: Raymond Cooper (PhytoScience Inc., Mountain View, California, USA) , John K. Snyder (Boston University, Massachusetts, USA)Publisher: Taylor & Francis Inc Imprint: Marcel Dekker Inc Dimensions: Width: 15.20cm , Height: 2.90cm , Length: 22.90cm Weight: 0.816kg ISBN: 9780824771164ISBN 10: 0824771168 Pages: 512 Publication Date: 22 July 1999 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Out of Print Availability: Out of stock  Table of ContentsInsect antifeeding limonoids from the chinaberry tree melia azedarach linn and related compounds; polygodial and warburganal, antifungal sesquiterpene dialdehydes and their synergies; marine bromoperoxidases-chemoenzymatic applications; LC-hyphenated techniques in the search for new bioactive plant constituents; determination of the absolute configuration of biologically active compounds by the modified Mosher's method; circular dichroism spectroscopy and the absolute stereochemistry of biologically active compounds; recent applications of circular dichronism to carbohydrate conformational analysis and direct determination of drug levels; furan-terminated cationic pi-cyclization in the synthesis of natural products; chemistry and biology of semisynthetic avermectins; chemical and biological approaches to molecular diversity - applications to drug discovery; imidazoline receptors and their endogenous ligands; oxidoredox suppression of fungal infections by novel pharmacophores; a mechanistic analysis of C-O bond cleavage events with a comparison to 3,6-dideoxysugar formation; the molecular mechanism of amyloidosis in Alzheimer's disease; bacteriorhodospin structure/function studies -use of the dimethyl retinal analogs for probing of the Arg82Ala mutant; autonomous genomes; stereo-chemical considerations of immunoglobulin heavy chain enhancer activation.Reviews... an interesting book...and a nice tribute to an outstanding scientist. ---Chromatographia ... with its breadth of coverage of important topics in biological chemistry and very high level of scholarship, this is an exceptionally fine tribute to one of the most influential scientists (Koji Nakanishi) of our era. Congratulations to all associated with the project! ---Pharmanex Under the editorship of Ray Cooper and John Synder, a number of the former students and postdoctoral researchers trained in Professor Koji Nakanishi's laboratory at Columbia University have produced an exceptionally fine tribute to him though a collection of 17 chapters on various specialized topics in biological chemistry.... ...with its breadth of coverage of important topics in biological chemistry and very high level of scholarship, this is an exceptionally fine tribute to one of the most influential scientists of our era. Congratulations to all associated with the project! ---Journal of Natural Products Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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