Overview

'In-depth coverage of the principles of cell signalling... will be an essential purchase for researchers and teachers in this area.' -ChemBioChem 'This useful production by Ernst Helmrich is beautifully presented by Oxford University Press. Each contribution is lucid, well illustrated and accompained by extensive reference lists... [a] labour of love... this is a solid enough reference book for the general research student, post-doc and senior investigator who needs to get a reasonable background to cell signalling... a very readable and useful book for background knowledge.' -Cell Biology International 'Recommended for everyone working in the area of signal transduction research, who should keep this book at hand for when they want to clarify a particular mechanism or connection again, and to get quick access to the most important original papers and review articles.' -Angewandte ChemieThe Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained by describing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ß in morphogenesis; cytokine signalling that controls haemopoiesis. There is also a discussion of the insulin response.

Full Product Details

Author:   Ernst Helmreich (Department of Physiological Chemistry, School of Medicine, Julius-Maximileians University of Wurzburg)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 16.90cm , Height: 2.00cm , Length: 24.00cm
Weight:   0.637kg
ISBN:  

9780198508205

ISBN 10:   0198508204
Pages:   352
Publication Date:   19 July 2001
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Abbreviations Part 1: The Machinery of Signal Transduction 1: Molecular basis of signal transduction 2: Activation of receptors by oligomerization 3: Components of signalling networks: linkers and regulators 4: Signal transduction pathways through small monomeric G proteins 5: Signal transduction pathways through heterotrimeric G proteins: transmission of hormonal and sensory signals 6: Signal transduction pathways controlling morphogensis and haematopoiesis 7: Control of signalling by phosphorylation and dephosphorylation 8: Regulation by a hormone: the insulin response Part 2: Cell Signalling and Gene Transcription 9: Machinery of gene transcription 10: Regulation of gene transcription by growth factors and cytokines 11: Regulation of gene transcription by hormones Part 3: Global Cell Regulatory Programmes 12: Regulation of the cell cycle 13: Regulation of cell death 14: Regulation of the immune response Part 4: Loss of the Regulatory Control and its Consequences 15: Transformation of normal cells to tumour cells 16: Loss of developmental controls in cancer 17: The causes of cancer Glossary Index

Reviews

There is an excellent style and graphic work thoughout the textbook supported by a glossary and an index. Graduate students, post docs and all researchers, who want to understand how cellular activities are organized and regulated, will highly welcome this book. Journal of Plant Physiology In-depth coverage of the principles of cell signalling ... will be an essential purchase for researchers and teachers in this area. ChemBioChem This useful production by Ernst Helmrich is beautifully presented by Oxford University Press. Each contribution is lucid, well illustrated and accompained by extensive reference lists ... [a] labour of love ... this is a solid enough reference book for the general research student, post-doc and senior investigator who needs to get a reasonable background to cell signalling ... a very readable and useful book for background knowledge. Cell Biology International Recommended for everyone working in the area of signal transduction research, who should keep this book at hand for when they want to clarify a particular mechanism or connection again, and to get quick access to the most important original papers and review articles. Angewandte Chemie

There is an excellent style and graphic work thoughout the textbook supported by a glossary and an index. Graduate students, post docs and all researchers, who want to understand how cellular activities are organized and regulated, will highly welcome this book. Journal of Plant Physiology In-depth coverage of the principles of cell signalling ... will be an essential purchase for researchers and teachers in this area. ChemBioChem This useful production by Ernst Helmrich is beautifully presented by Oxford University Press. Each contribution is lucid, well illustrated and accompained by extensive reference lists ... [a] labour of love ... this is a solid enough reference book for the general research student, post-doc and senior investigator who needs to get a reasonable background to cell signalling ... a very readable and useful book for background knowledge. Cell Biology International Recommended for everyone working in the area of signal transduction research, who should keep this book at hand for when they want to clarify a particular mechanism or connection again, and to get quick access to the most important original papers and review articles. Angewandte Chemie

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