Overview

This is a review of developments in the mechanisms of retinoid action, the spectrum of biological response to retinoids and their potential use in cancer therapy. Retinoid structure, chemistry and biologically active derivatives are discussed in detail together with molecular mechanisms of retinoid function. Retinoids play a significant role in embryonic development and pattern formation and this topics has gained a prominent place in this book. Views propounded here are the involvement of retinoids in cellular responses to growth factor and signal transduction, the role of retinoids in apoptosis and in cancer cell adhesion, invasion and metastasis. The discussion of the therapeutic aspects of retinoids as a modality of cancer treatment is focused on breast and lung cancer management, and on the use of retinoids in the treatment of tumours of the nervous system. In essence, this is an examination of the basic biology of retinoid function and focuses upon their therapeutic potential. It aims to stimulate further fundamental research into the varied physiological functions of retinoids and their application to the disease states.

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