Overview

Residual dipolar couplings (RDCs) are NMR measurements widely used to determine structural and dynamic information in small molecules and large macromolecules. This book provides a broad view of RDCs, from basic principles to advanced applications in organic molecules and biomolecules. Exploring the newest developments in RDC measurement and analysis through authoritative accounts written by leaders in the field, this book provides a comprehensive overview on the fundamentals, analysis and applications in one place for the first time. The versatility and accuracy of RDCs have found a large range of applications in NMR, and their measurement and analysis are major research areas. Readers, be they experts or students, will receive a strong understanding of the fundamentals of RDCs and their applications to their research projects.

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9781839164293

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Professor Lishan Yao is an expert in protein solution NMR and molecular dynamics simulation. He has developed several NMR methods combined with MD simulations in studying protein noncovalent interactions (electrostatics, hydrogen bonds, van der Waals, and etc.). He has also developed residual dipolar couplings (RDCs) methods to determine protein structure and conformational dynamics. His research interests focus on studying protein conformational properties and weak interactions, and their impact on protein function. Professor Justin Lorieau is an expert in solution and solid-state NMR with 20 years’ experience. He has published on new techniques to measure dynamics from dipolar couplings in solid-state NMR, new alignment media to measure RDCs in solution NMR, the fundamental theory of RDCs in relation to molecular symmetry, the integration of RDCs with solid-state NMR analysis and the application of RDCs to solve ensemble structures for dynamic molecules. His research program investigates new NMR developments and the application of NMR in the study of viral proteins and amyloidogenic disease.

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