Overview

This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.

Full Product Details

Author:   Claus Jacob (Saarland University, Germany) ,  Paul G. Winyard (Universities of Exeter and Plymouth, Great Britain)
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Blackwell Verlag GmbH
Dimensions:   Width: 17.50cm , Height: 2.30cm , Length: 24.40cm
Weight:   1.089kg
ISBN:  

9783527319251

ISBN 10:   3527319255
Pages:   514
Publication Date:   22 April 2009
Audience:   College/higher education ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Introduction Biological Systems Relevant for Redox Signaling and Control Cellular Generation of Oxidants: Relation to Oxidative Stress The Chemical Basis of Biological Redox Control Protein Glutathiolation Structure and Function of the Human Peroxiredoxin-Based Antioxidant System: the Interplay between Peroxiredoxins, Thioredoxins, Thioredoxin Reductases, Sulfiredoxins and Sestrins Hydrogen Peroxide and Cysteine Protein Signaling Pathways Protein Tyrosine Phosphatases as Mediators of Redox Signaling Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1a Eicosanoid-Based Signaling Redox-Controlled Transcription Factors and Gene Expression Nitric Oxide Regulation in Redox Signaling Is Hydrogen Sulfide a Regulator of Nitric Oxide Bioavailability in the Vasculature? Aspects of Nox/Duox Signaling Photodynamic Therapy with Aminolevulinic Acid and Iron Chelators: A Clinical Example of Redox Signaling Oxidative Stress and Apoptosis Redox Regulation of Apoptosis in Immune Cells Redox Control in Human Disease with a Special Emphasis on the Peroxiredoxin-Based Antioxidant System Free Radicals and Mammalian Aging

Reviews

Author Information

Claus Jacob is Junior Professor of Bioorganic Chemistry at the School of Pharmacy, University of Saarland, Germany. He studied chemistry in Kaiserslautern, Germany, and Leicester, UK, subsequently earning his doctorate from the University of Oxford. From 1996 until 1999 he was a postdoc under Prof. Bert Vallee at Harvard Medical School, before taking up the position of lecturer in inorganic chemistry at the University of Exeter, where he remained until moving to his current position in 2005. Claus Jacob is currently coordinator of the EU Framework 7 Marie Curie Initial Training Network on ""Natural Products and related Redox Catalysts: Basic Research and Applications in Medicine and Agriculture"". His particular interest is in the chemistry underlying biochemical redox events, most notably reactive sulfur species. Paul Winyard is Professor of Experimental Medicine at Peninsula College of Medicine and Dentistry, Exeter, UK (since 2002). He previously held a Chair in Experimental Medicine at St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK, and was a Visiting Professor at the University of California, San Francisco (2000-2001). Paul's research interests centre on the role of oxidative/nitrosative stress in human chronic inflammatory diseases such as rheumatoid arthritis. In particular, he has focused on the development of novel therapeutic strategies and free radical assays, and the translation of these developments into preclinical and early-phase clinical studies.

Tab Content 6

Author Website:  

Countries Available

All regions