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OverviewA volume in the Molecular and Cellular Neurobiology series. This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states. The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to cover ligand-gated ion channels with two chapters on acetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors. Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology. Full Product DetailsAuthor: Stephen J. Moss (, MRC-LMCB & Department of Pharmacology, University College London, UK) , Jeremy Henley (, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, UK)Publisher: Oxford University Press Imprint: Oxford University Press Dimensions: Width: 17.40cm , Height: 1.80cm , Length: 24.80cm Weight: 0.646kg ISBN: 9780192632241ISBN 10: 0192632248 Pages: 236 Publication Date: 22 August 2002 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsIon Channels 1: Malik-Hall, Wood & Okuse: Voltage-gated sodium channels 2: Tinker: The assembly and targeting of potassium channels 3: Dolphin: Assembly and targeting of voltage-dependent calcium channels Acetylcholine Receptors 4: Swope: Targeting of acetylcholine receptors to the postsynaptic endplate of the nerve-muscle synapse 5: Millar: Assembly and targeting of neuronal nicotinic acetylcholine receptors Amino Acid Receptors 6: Stricker & Huganir: AMPA/kainate receptors 7: Hering & Sheng: NMDA receptor targeting 8: Harvey, von der Nuell & Harvey: Structure, assembly and targeting of glycine receptors 9: Luscher: GABAA and GABAC receptors: regulation of assembly, localization, clustering and turnoverReviewsThe editors and authors have done an excellent job ... Moss and Henley make a valuable contribution by highlighting major advances in the membrane trafficking of specific neurotransmitter receptors and ion channels ... this book is a most interesting and thought-provoking read. Nature Cell Biology """The editors and authors have done an excellent job ... Moss and Henley make a valuable contribution by highlighting major advances in the membrane trafficking of specific neurotransmitter receptors and ion channels ... this book is a most interesting and thought-provoking read."" Nature Cell Biology" ""The editors and authors have done an excellent job ... Moss and Henley make a valuable contribution by highlighting major advances in the membrane trafficking of specific neurotransmitter receptors and ion channels ... this book is a most interesting and thought-provoking read."" Nature Cell Biology Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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