Overview

Leading researchers summarize and describe their experience and techniques for synthesizing oligonucleotides and their analogs. The protocols presented cover all DNA analogs that have been studied to date and constitute the single most extensive source of knowledge about DNA chemistry available.

Full Product Details

Author:   Sudhir Agrawal
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1993 ed.
Volume:   20
Dimensions:   Width: 15.50cm , Height: 2.80cm , Length: 23.50cm
Weight:   1.990kg
ISBN:  

9780896032811

ISBN 10:   0896032817
Pages:   502
Publication Date:   31 August 1993
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

A Brief History of Oligonucleotide Synthesis.- Oligonucleotide Synthesis.- Oligodeoxyribonucleotides Synthesis.- Oligodeoxynucleotide Synthesis.- Oligoribonucleotide Synthesis.- Synthesis of 2?-O-Alkyloligoribonucleotides.- An Improved Method for the Synthesis and Deprotection of Methylphosphonate Oligonucleotides.- Oligonucleoside Phosphorothioates.- Synthesis and Purification of Phosphorodithioate DNA.- Oligodeoxyribonucleotide Phosphotriesters.- Oligonucleoside Boranophosphate (Borane Phosphonate).- Oligonucleotide Phosphorofluoridates and Fluoridites.- ?-Oligodeoxynucleotides.- Stereospecific Synthesis of P-Chiral Analogs of Oligonucleotides.- Oligonucleotide Analogs with Dimethylenesulfide, -sulfoxide, and -sulfone Groups Replacing Phosphodiester Linkages.- Oligonucleotide Analogs Containing Dephospho-Internucleoside Linkages.- Scale-Up of Oligonucleotide Synthesis.- Large-Scale Oligonucleotide Synthesis Using the Solid-Phase Approach.- Solid-Phase Supports for Oligonucleotide Synthesis.

Reviews

...comprehensive and authoritative definitely required reading for the would-be oligonucleotide chemist and for those involved in biological applications of oligonucleotides... - Journal of Pharmacy and Pharmacology

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