Overview

Cell biology is a rapidly developing discipline which brings together many of the branches of the biological sciences which were separate in the past. The twentieth century has witnessed the development of a huge and diverse range of tools and techniques (physical, chemical and biological) which have irrevocably changed the study of cell biology, making it cross boundaries, link the molecule with the organelle and the cellular response with the larger organism. These interrelations between cell structures and function at the molecular and subcellular level are the central connecting theme of this study. In this volume, experts in the field review the central aspects of mitochondrial biogenesis. The logical order of the 16 chapters is determined by the sequence of steps during protein import, starting with the events taking place in the cytosol, followed by the recognition of targeting signals, the translocation of precursor proteins across the outer and inner membranes, their proteolytic processing and intramitochondrial sorting, and finally their folding and oligomeric assembly. In addition, the mechanisms involved in the export of mitochondrially encoded proteins as well as recent advances in understanding the division and inheritance of mitochondria is discussed.

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