Overview

Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects joints and bones. Disease‑modifying anti‑rheumatic drugs, biologics, and NSAIDs are mostly acclaimed for symptomatic relief, but these may have adverse outcomes. Extensive research has been conducted to find alternative and safe treatment options for RA. Phytochemicals in the Management of Rheumatoid Arthritis examines advanced knowledge about pathogenesis, diagnosis, and conventional treatment of RA and the application of phytochemicals in the management and prophylaxis of RA through modulation of molecular targets such as matrix metalloproteinases, nuclear factor kappa B, arachidonic acid, RANKL, and JAK/STAT. This book contains research on the mechanisms of action, dosage, and molecular pathways affected by phytochemicals to treat RA and emphasizes the targeted‑drug delivery and novel dosage forms of phytochemicals to improve therapeutic efficacy and abate adverse effects. Additionally, it provides information on clinical studies and the use of photodynamic therapy for the management of RA. It will equip postgraduate students, health professionals, practitioners, pharmaceutical researchers, and biomedical scientists with valuable evidence about the anti‑arthritic foods, nutrients, and phytochemicals required for treating RA.

Full Product Details

Author:   Ammara Saleem ,  Muhammad Furqan Akhtar ,  Alam Zeb
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
ISBN:  

9781032860862

ISBN 10:   1032860863
Pages:   274
Publication Date:   14 July 2026
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

Section A Chapter 1: Introduction to chemistry of phytochemicals Alam Zeb Chapter 2: Introduction to Rheumatoid arthritis Mehak Fatima, Ammara Saleem, Justyna Wozniak, Muhammad Furqan Akhtar Chapter 3: Current pharmacotherapy for Rheumatoid arthritis Mehak Fatima, Ammara Saleem, Aisha Mobashar, Muhammad Furqan Akhtar Chapter 4: Combination therapy and dual inhibition of signaling pathways in Rheumatoid arthritis Tanzeela Awan, Uzma Saher, Justyna Wozniak, Ayesha Fatima, Ammara Saleem Section B Chapter 5: Phytochemicals targeting Nuclear factor kappa B and matrix metalloproteinases pathways to treat Rheumatoid arthritis Hamna Mehmood, Ammara Saleem, Aisha Mobashar, Muhammad Furqan Akhtar, Justyna Wozniak, Joham Javed Chapter 6: Phytochemicals targeting arachidonic acid pathway to treat Rheumatoid arthritis Aisha Shehzad, Aqsa Mushtaq , Hafiza Sidra Yaseen, Ammara Saleem Chapter 7: Phytochemicals targeting JAK/STAT pathway to treat Rheumatoid arthritis Sara Zahid, Sampath Chinnam, Sana Kashan, Ammara Saleem Chapter 8: Phytochemicals targeting PI3K/Akt/mTOR signaling pathway to treat Rheumatoid arthritis Ramla Shabbir, Rukhsar Imran, Shaneel Kousar, Yusuf Tatur, Ammara Saleem Chapter 9: Phytochemicals targeting transforming growth factor (TGF)-β and Inducible nitric oxide synthase to treat Rheumatoid arthritis Humaira Gul, Rida Siddique, Muntaha Maqbool, Noor-ul-Eman, Atika Afzal, Faraza Javaid, Yusuf Tatur, Ammara Saleem Chapter 10: Phytochemicals targeting Vascular endothelial growth factor (VEGF) and RANKL pathway in the treatment of Rheumatoid arthritis Rida Siddique, Muhammad Asim Shehzad, Rabia Arshad, Ammara Saleem Chapter 11: Clinical studies about phytomedicines for the management of Rheumatoid arthritis Atika Afzal, Ayesha Mahmood, Shaneel Kousar, Sajid Ali, Ammara Saleem Section C Chapter 12: Phytochemicals as nutraceuticals in the management of Rheumatoid arthritis Shakila Sabir, Muhammad Naeem, Ammara Saleem, Ghulam Md Ashraf, Muhammad Furqan Akhtar Chapter 13: Adverse effects of phytochemicals used to treat Rheumatoid arthritis Shakila Sabir, Muhammad Ejaz-ul-Haq, Ammara Saleem, Syed Haroon Khalid, Muhammad Furqan Akhtar Section D Chapter 14: Novel pharmaceutical dosage forms of Phytochemicals for the treatment of Rheumatoid arthritis Samia Gul Niazi, Mahdia Arshad, Chanda Javed, Shahida Shaeen, Anil Ahsan, Muhammad Furqan Akhtar, Ammara Saleem Chapter 15: Photodynamic therapy using photoactive phytochemicals Maria Tahir, Ammara Saleem, Qadeer Ahmad, Muhammad Furqan Akhtar, Mirza Muhammad Faran Ashraf Baig, Muhammad Imran Khan Chapter 16: Pharmaceutical and regulatory considerations, and future prospective of Phytomedicines and nutraceuticals Ejaz Basheer, Shahid Rasool, Muhammad Talha, Muhammad Najeeb Ullah, Ammara Saleem, Mhammad Furqan Akhtar

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Author Information

Dr. Ammara Saleem is the Assistant Professor, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan. She has published more than 117 research papers in renowned journals with impact factor more than 440. She has 11 years of teaching and research experience. Her specific research area is inflammatory diseases, metabolic disorders, neurological and immunological disorders. She has published various research articles regarding medicinal plants for the treatment of inflammatory and immune disorders. She is the editorial board member in BioMed research international journal and Canadian respiratory journal. She has reviewed for different well reputed international scientific journals such as Molecules, Food, Frontier in Pharmacology etc. Dr. Muhammad Furqan Akhtar is the Associate Professor, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Pakistan. He has fourteen years of teaching and research experience. He is the author of more than 150 peer reviewed ISI-indexed articles with a cumulative impact factor of 500. He has supervised more than 49 post-graduate pharmacology students and is serving as academic/Associate editor of several prestigious international journals such as international journal of Endocrinology, Plos One. Evidence based complementary and alternative medicine, Frontier in Pharmacology, Heliyon. His research work focusses on pre-clinical exploration of neurological, endocrine, metabolic and immune diseases such as infertility, polycystic ovarian syndrome, obesity, drug induced infertility, diabetes and arthritis by drug-repurposing, nutraceuticals and, natural and synthetic drugs in animal models of disease and in-vitro methods. More specifically, he carries out research to investigate the role of potential drugs in ameliorating oxidative stress, genotoxicity and inflammation through a range of molecular and biochemical techniques so as to elucidate their mechanism of action. At larger scales, He is interested in the treatment of neurological and endocrine diseases, immune-stimulation as well as phytomedicines and ethnopharmacology. He also investigates the potential health hazardous effects, especially genotoxicity, endocrine disruption and neuro-degenerative diseases associated with the environmental pollutants such as microplastics and herbicides, so as to develop strategies to overcome these problems. Through these studies, he has investigated, compared and corroborated a range of nutraceuticals, herbal remedies and repurposed drugs for the management of various chronic ailments. Dr. Alam Zeb is a Professor of Biochemistry. He currently works in The Bioactive Lab, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. He worked for 21 years at the Department of Biochemistry, University of Malakand, Pakistan. He is serving for 22 years at the same university teaching chemistry and biochemistry courses to undergraduate, graduate and postgraduate students of biotechnology and biochemistry. Dr. Zeb has received his PhD with distinction from the Institute of Biochemistry, Technical University of Graz, Austria. Dr. Zeb published more than 109 research articles regarding the subject in various international peer-reviewed journals. Dr. Zeb had authored two books, the recent one is a textbook “Phenolic antioxidants in Foods: Chemistry, Biochemistry and Analysis” published by Springer Nature, Switzerland in 2021. The second textbook “Food Frying: Chemistry, Biochemistry and Safety” had been published by John Wiley and Sons, UK, in 2019. This book has been ranked 4th among the best top 10 books of all times in the field of chemistry and safety by Bookauthority.org. He had supervised several PhD and MPhil research students during his service at the University of Malakand. He is a member of the editorial board of several international journals including Frontiers in Nutrition, Journal of Food Processing and Preservation, and Current Functional Foods. Dr. Zeb is a productive scientist of Pakistan since 2009 and had received research productivity awards from Pakistan Council for Science and Technology, Pakistan, for several consecutive years, representing his contribution in the field of biochemistry.

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