Overview

Parkinson's disease is a multifaceted neurological condition characterized by a variety of motor and nonmotor symptoms that lead to movement impairment as well as a wide array of nonmotor issues, such as autonomic dysfunction, depression, cognitive impairments, and neuropsychiatric symptoms. Parkinson's disease ranks as the second leading cause of neurological disability in the elderly, following Alzheimer’s disease. Parkinson's disease is a global condition, with its prevalence rising dramatically among individuals aged 65 to 90 years. The average age at which symptoms begin is approximately 65 years. As the global population continues to grow, particularly among older individuals, it is anticipated that the incidence of Parkinson's disease will rise in the coming years. This disease is caused by the gradual and selective degeneration of the pigmented dopamine-producing neurons located in the substantia nigra pars compacta (SNpc) of the midbrain. Although the exact cause leading to nigrostriatal cell death remains elusive, considerable progress has been made in understanding the pathogenesis of the disease and managing its symptoms. This book offers a succinct and current overview of the existing knowledge on Parkinson's disease, covering aspects such as epidemiology, etiology, neuropathology, and diagnosis, with a focus on the key characteristics of Parkinson's disease. It also addresses non-motor symptoms, including psychological aspects, differential diagnosis, associated disorders, the natural progression of Parkinson's disease and its functional stages, clinical phenotypes, genetics, non-genetic influences, as well as treatment strategies and responses to therapies, including potential neuroprotective agents. The significance of this book lies in its comprehensive summary of various facets of Parkinson’s disease, which are rarely compiled in such a manner in other literature. It provides extensive coverage of these topics and valuable insights into this intricate neurological condition. The book presents crucial information about major advancements in the field in a clear and accessible format, making it suitable for both clinicians and researchers in the field.

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Department of Toxicology and Narcotics, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.

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