p53 Suppressor Gene
Author:   Tapas Mukhopadhyay ,  J. A. Roth ,  S.A. Maxwell
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Edition:   illustrated edition
ISBN:  

9783540590828


Pages:   143
Publication Date:   01 May 1995
Format:   Hardback
Availability:   Out of stock   Availability explained
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p53 Suppressor Gene


Overview

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

Full Product Details

Author:   Tapas Mukhopadhyay ,  J. A. Roth ,  S.A. Maxwell
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   illustrated edition
Weight:   0.595kg
ISBN:  

9783540590828


ISBN 10:   354059082
Pages:   143
Publication Date:   01 May 1995
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

1. The Role of p53 in Cancer.- 2. Gene Structure.- 3. Wild-Type versus Mutant p53.- 4. Biophysical and Biochemical Properties of the p53 Protein.- 5. Regulation and Modulation of the Function of p53.- 6. Potential Clinical Significance of the p53 Tumor Suppressor Gene in Cancer Patients.

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