Overview

Leading researchers present those techniques that have been crucial to propelling the neurotrophic factors field to its current state of high visibility. The techniques range from molecular biological methods used for cloning and production, to cell culture methods for assessing biological activities, to animal models of nervous system injury (necessary for the development of therapeutic agents from neurotrophic factors).

Full Product Details

Author:   Alan A. Boulton ,  Glen B. Baker ,  Franz Hefti
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1993 ed.
Volume:   25
Dimensions:   Width: 15.50cm , Height: 2.80cm , Length: 23.50cm
Weight:   1.810kg
ISBN:  

9780896032491

ISBN 10:   0896032493
Pages:   422
Publication Date:   16 August 1993
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Purification and Microsequencing of Neurotrophic Proteins.- Identification of Neurotrophic Factors by Molecular Biological Techniques.- Visualization and Quantitation of Neurotrophin mRNAs.- Molecular Analysis of Neurotrophin Genes.- Production of Recombinant Neurotrophic Factors.- Production of Genetically Engineered Cells Releasing Neurotrophic Factors.- Characterization and Localization of Receptors for Neurotrophic Factors.- Transgenic Expression of Neurotrophic Factors and Their Receptors.- Retrograde Axonal Transport.- Experimental Systems to Study Neurotrophic Factor Effects on Rat Brain Cells.- Nonhuman Primate Models in Trophic Factor Research.- Models to Evaluate Effects of Neurotrophic Factors on Axonal Regeneration.

Reviews

...strength of the book lies in the comprehensive methodology...a welcome addition to any neurobiologist's library. - Journal of Neurochemistry

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