Overview

Prominent researchers and clinicians dissect the signaling pathways of an array of neuroprotective factors, ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5) to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur with injured neurons independently of intercellular signals. In elucidating the molecular cascades evolved by the nervous system to protect itself, the contributors lay the basis for powerful new drug discovery and gene therapy strategies, and shed light on potential effective strategies for preventing neuron degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.

Full Product Details

Author:   Mark P. Mattson
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1998 ed.
Dimensions:   Width: 17.80cm , Height: 2.00cm , Length: 25.40cm
Weight:   2.000kg
ISBN:  

9780896034730

ISBN 10:   0896034739
Pages:   347
Publication Date:   10 October 1997
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Neuroprotective Strategies Involving the Neurotrophins and Their Signaling Pathways.- Nerve Growth Factor and Its Receptors in the Primate Forebrain.- Molecular Mechanisms of Neuroprotection from Neuronal Death by Trophic Factor Deprivation.- Gene Induction and Neuronal Apoptosis.- Clinical Potential of Compounds That Stimulate Nerve Growth Factor Production.- Preclinical Trials of Basic Fibroblast Growth Factor (bFGF) in Animal Models of Stroke.- Transforming Growth Factor-? Signaling and Neuroprotection.- Protective and Regenerative Properties of GDNF in the Central Nervous System.- Tumor Necrosis Factor.- Neuroprotective Strategies Based on Interleukin Signaling.- Signaling by ?-Amyloid Precursor Protein.- Clinical Potential of Agents That Affect Thrombin Signaling in Degenerative and Traumatic Neurologic Disorders.- Thrombin and Thrombin Inhibitors.- Deleterious and Salutary Effects of Steroid Hormones in the Nervous System.- Therapeutic Potential of Leukocyte Antiadhesion Strategies in CNS Ischemia.- Neuroprotective Strategies Based on Targeting of Postreceptor Signaling Events.

Reviews

Author Information

Tab Content 6

Author Website:  

Countries Available

All regions