Molecular Targets in Protein Misfolding and Neurodegenerative Disease
Author:   Pierfausto Seneci (Associate Professor, Department of Organic and Industrial Chemistry, University of Milan, Milan, Italy)
Publisher:   Elsevier Science Publishing Co Inc
ISBN:  

9780128001868


Pages:   314
Publication Date:   09 October 2014
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Molecular Targets in Protein Misfolding and Neurodegenerative Disease


Overview

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Full Product Details

Author:   Pierfausto Seneci (Associate Professor, Department of Organic and Industrial Chemistry, University of Milan, Milan, Italy)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 15.20cm , Height: 2.00cm , Length: 22.90cm
Weight:   1.260kg
ISBN:  

9780128001868


ISBN 10:   0128001860
Pages:   314
Publication Date:   09 October 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Protein misfolding, neurodegeneration and Tau: The main players, or the usual suspects? 2. Targeting the protein quality control (PQC) machinery: The neuronal Salvation Army 3. Proteasomal degradation of soluble, misfolded proteins: Throwing out the bath water, but where’s the baby? 4. Unselective disposal of cellular aggregates: Engulf, devour and digest to recycle 5. Selective disposal of insoluble protein aggregates: Pick, transport and remove to cure 6. Assembly and disassembly of protein aggregates: Unraveling the maze

Reviews

""...an excellent biology-oriented discussion of the role of protein misfolding in neurodegenerative diseases...along with the forthcoming companion book, will provide neuroscientists with a strong foundation in this very important topic. Score: 88 - 3 Stars"" --Doody's


...an excellent biology-oriented discussion of the role of protein misfolding in neurodegenerative diseases...along with the forthcoming companion book, will provide neuroscientists with a strong foundation in this very important topic. Score: 88 - 3 Stars --Doody's, Molecular Targets in Protein Misfolding and Neurodegenerative Disease


...an excellent biology-oriented discussion of the role of protein misfolding in neurodegenerative diseases...along with the forthcoming companion book, will provide neuroscientists with a strong foundation in this very important topic. Score: 88 - 3 Stars --Doody's


Author Information

Dr. Pierfausto Seneci is Associate Professor in the Department of Organic and Industrial Chemistry at the University of Milan. He is currently affiliated with the University of Milan Centre for Interdisciplinary Biomolecular Studies and Industrial Applications (CISI) Centre of Excellence, and is responsible for the Combinatorial Chemistry/High Throughput MedChem Laboratory. He has over 20 years of medicinal chemistry experience working in industry, and held business development positions with GSK, Sanofi, and start-up pharmaceutical companies including Sirenade and NiKem working in drug discovery, neurodegeneration, oncology, and antibacterials. He is author of approximately 80 papers on the topic and several book chapters, including the book “Solid-Phase Synthesis and Combinatorial Technologies” with Wiley-Interscience in 2000.

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