Overview

Work in molecular biology and the genetics of cancer is becoming increasingly crucial for the development of new diagnostic procedures and therapeutical strategies in oncology. Presented here is an excellent series of reviews and research papers by recognised specialists reporting on the most recent achievements in the field and on how these can be applied in clinical practice. The aim of this comprehensive overview is to close the gap that separates the bench from the bedside.

Full Product Details

Author:   A. Cittadini ,  Renato Baserga ,  H. M. Pinedo ,  Tammaso Galeotti
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Weight:   1.030kg
ISBN:  

9783764329150

ISBN 10:   3764329157
Pages:   437
Publication Date:   01 July 1993
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Molecular aspects of cell transformation and growth.- The Impact of Molecular Genetics on Cancer Research.- Identification of a Chimeric Gene Frequently Activated in Human Thyroid Papillary Carcinomas.- The Role of Tumor Suppressor Genes in Human Cancer Progression.- The Central Role of the IGF-1 Receptor in the Control of Cellular Proliferation.- Loss of TGF-ss Expression is a Critical Component of Malignant Progression in Multistage Carcinogenesis of the Mouse Epidermis.- Structure, Biosynthesis and Biochemical Properties of the HGF/SF Receptor.- Molecular Characterization of Trop-2, a Cell Surface Molecule Highly Expressed by Human Carcinomas - Cloning of the Gene Encoding Trop-2.- Loss of Heterozygosity and Distribution of Alleles at the VNTR Region of the HRAS Gene in Ovarian Carcinoma.- Mg2+ in the Regulation of Ascites Tumor Cell Energy Metabolism.- Effect of Quercetin on Cell Proliferation and Heat Shock Protein Synthesis Induction in K562 Erythroleukemia.- Regulation of MnSOD Expression by Manganese in Tumors.- Membrane receptors and signal transduction.- An Efficient Expression cDNA Cloning Approach to Screen Human Tumors for Oncogenes.- The Roles of Specific Isoforms of Protein Kinase C (PKC) in Signal Transduction, Growth Control and Diacylglycerol Metabolism.- Regulation of Protein Kinase C.- Potential Roles of p21ras in Growth Factor Signalling - An Overview.- p21-ras and p56-lck Mediate The Two Major T-Cell Antigen Receptor Signal Transduction Pathways.- Further Characterization of CDC25 Mm , a Mammalian Activator of p21ras.- MAP Kinase Cascade and the Control of Cell Proliferation.- Accumulation and Mitogenic Activity of Lysophosphatidylinositol in k-ras-Transformed Thyroid Cells.- Activities Involved in the Modulation of the G Protein Endogenous ADP-Ribosylation in Normal and K-ras-Transformed Thyroid Cells.- The Regulation of TNF-? Receptors in Human Osteosarcoma Cells.- Chronic Exposure to the Tumor Promoter TPA Mimics Differentiating Effects of Serum in Primary Cultures of Cerebellar Granules.- Transcriptional Control by Nuclear Receptors.- Models for new therapeutical strategies.- Therapeutic Opportunities Involving Cellular Oncogenes.- Molecular Analysis of Fine Needle Aspiration Cytologic Specimens from Suspicious Thyroid Nodules.- Tumor-associated Macrophages: Cytokine Regulation and Therapeutic Implications.- Various Cytokines (IL-2, IL-4, IFN-gamma) Show Different Efficiency in Inducing Tumor Rejection.- Adoptive Immunotherapy of Melanoma with Interleukin-2 and Lymphocytes.- GM-CSF Augments the IL-4 Induced Cytotoxic Activity of Human Peripheral Blood Mononuclear Cells in the Presence of the Mouse Monoclonal Antibody 17-1A.- Autologous Bone Marrow Transplantation with Peripheral Stem Cells In vivo Expanded by Chemotherapy and G-CSF.- The Regulatory Subunit of cAMP-Dependent Protein Kinase as a Target for Cancer Diagnosis and Therapy.- Type I Isoform of PKA is Involved in the Control of Cell Proliferation and Oncogene Transformation of Human Mammary Epithelial Cells: Therapeutic Implications.- Modulation of the Cell Response to Hyperthermia by Membrane Perturbating Agents.- MRS Studies on Experimental Tumours Treated with TNF.- Tumor Vaccines - Perspectives and Practice.- Clinical applications.- Tumor Imaging with Radiolabeled Monoclonal Antibodies and Other Specific Ligands.- Evaluation of p53 Overexpression in Bladder Cancer.- Biological Factors and Treatment Decision in Early Breast Cancer.- New Chemotherapeutic Agents: A Selection of Some of the Most Promising New Drugs.- Degradation of 5-Fluorouracil via the Pyrimidine Degradative Pathway.- Folinic Acid and 5-Fluorouracil +- Interferon Alfa-2b in the Treatment of Advanced Colorectal Cancer: Preliminary Results of a Randomized Study.- Pharmacokinetics of Free and Total Platinum Species after Prolonged Venous Infusion of Cisplatin and Concurrent Radiation Therapy for Lung Carcinoma.- The Role of Interferons in the Treatment of Solid Tumors.- Endocrine Treatment of Malignant Disease.- Interactions Between Growth Factors and Oestrogens in Breast Cancer Cells.- Potentiation of the Antitumor Activity of Tamoxifen by Interferons: A Mini-Review.- Vitamin E status is Influenced by ?-3 Polyunsaturated Fatty Acid Supplementation in Patients at Risk for Colon Cancer.- Progress Towards the Clinical Application of Somatic Cell Gene Therapy.- Intraoperative Radiation Therapy: An Overview.

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