Overview

The latest knowledge on molecular motors is vital for the understanding of a wide range of biological and medical topics: cell motility, organelle movement, virus transport, developmental asymmetry, myopathies, and sensory defects are all related to the function or malfunction of these minute molecular machines. Since there is a vast amount of information on motor mechanisms and potential biomedical and nanobiotechnological applications, this handbook fulfills the need for a collection of current research results on the functionality, regulation, and interactions of cytoskeletal, DNA, and rotary motors. Here, leading experts present a concise insight, ranging from atomic structure, biochemistry, and biophysics to cell biology, developmental biology and pathology. Basic principles and applications make this book a valuable reference tool for researchers, professionals, and clinicians alike - all set to become a ""classic"" in the years to come.

Full Product Details

Author:   M Schliwa
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Wiley-VCH Verlag GmbH
Dimensions:   Width: 18.60cm , Height: 3.50cm , Length: 24.60cm
Weight:   1.354kg
ISBN:  

9783527305940

ISBN 10:   3527305947
Pages:   604
Publication Date:   21 January 2003
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

Preface.List of Contributors.PART 1: BASIC PRINCIPLES OF MOTOR DESIGN.The Myosin Superfamily: An Overview.Dynein Motors: Structure, Mechanochemistry and Regulation.Kinesin Superfamily Proteins.The Bacterial Flagellar Motor.F1-Motor of ATP Synthase.RNA and DNA Polymerases.Helicases as Molecular Motors.PART 2: MECHANOCHEMISTRY.How Protein Motors Convert Chemical Energy into Mechanical Work.Molecular Motor Directionality.Kinesins: Processivity and Chemomechanical Coupling.Quantitative Measurements of Myosin Movement In Vitro: The Reductionist Approach Carried to Single Molecules.Structures of Kinesin Motor Domains: Implications for Conformational Switching Involved in Mechanochemical Coupling.Single Molecule Measurements and Molecular Motors.PART 3: FUNCTIONAL IMPLICATIONS.Mitotic Spindle Motors.The Roles of Molecular Motors in Generating Developmental Asymmetry.Motors and Membrane Trafficking.Regulation of Molecular Motors.Molecular Motors in Plant Cells.PART 4: MOTORS IN DISEASE.Myosin Myopathies.The Role of Dynein in Disease.Molecular Motors in Sensory Defects.PART 5: BEYOND BIOLOGICAL APPLICATIONS.Systematized Engineering of Biomotor-powered Hybrid Devices. Synthetic Molecular Motors.Index.

Reviews

...a unique collection of chapters written by leaders who are well versed with this field...an excellent source for both professional and general readers... (Quarterly Review of Biology, March-May 2005) Molecular Motors is an excellent source book that provides much-needed up-to-date introduction and an important snapshot of current knowledge of a rapidly expanding field of biology. (Advanced Materials, September 3, 2004) ...essential reading for graduate students in the field of cell motility and molecular motors...recommend it enthusiastically... (Nature Cell Biology, Vol 6(1) 2004)

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