Overview

This volume provides a compilation of the main principles of signal transduction mechanisms. The reader will become familiar with the most recent developments on:- the structure and function of heterotrimeric G-proteins and their receptors;- the small GTPases Ras, Rho, Rab and Arf;- EGF receptor, Ca2+ and protein kinase C;- phosphoinositide kinases (PI-3 kinases);- phospholipases C and D;- ceramides and possible modulators of apoptosis;- transcription factors and gene activation;- multidrug resistance transporters.

Full Product Details

Author:   Karel W. A. Wirtz
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   illustrated edition
Volume:   v. 101
Weight:   0.645kg
ISBN:  

9783540628910

ISBN 10:   3540628916
Pages:   344
Publication Date:   19 June 1997
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Heterotrimeric and Small G-Proteins.- Heterotrimeric guanine nucleotide binding proteins: structure and function.- G-Protein coupled receptors: structure, functions and mutations.- Heterologous expression of G protein-coupled receptors in yeasts: an approach to facilitate drug discovery.- The role of small GTPases in signal transduction.- Small GTPases in the morphogenesis of yeast and plant cells.- A role for G-protein ??-subunits in the secretory mechanism of rat peritoneal mast cells.- Subcellular localisation of ARF 1-regulated phospholipase D in HL60 cells.- Intra-and Intercellular Communication.- Electrophysiological aspects of growth factor signaling in NRK fibroblasts: the role of intercellular communication, membrane potential and calcium.- Cross-talk between calmodulin and protein kinase C.- Endocytosis and Vesicle Flow.- A function for Eps15 in EGF-receptor endocytosis?.- Proteins, sorted. The secretory pathway from the endoplasmic reticulum to the Golgi, and beyond.- Lipids and Intracellular Signalling.- The roles of PI3Ks in cellular regulation.- Phosphatidylinositol transfer protein, phosphoinositides and cell function.- Receptor regulation of phospholipases C and D.- Ceramide: a central regulator of the cellular response to injury and stress.- Ceramide changes during FAS (CD95/APO-1) mediated programmed cell death are blocked with the ICE protease inhibitor zVAD.FMK. Evidence against an upstream role for ceramide in apoptosis.- The structure, biosynthesis and function of GPI membrane anchors.- Enzyme assisted synthetic approaches to the inositol phospholipid pathway.- Regulation of Nuclear Transcription.- Coupling signal transduction to transcription: the nuclear response to cAMP.- Vitamin E and the metabolic antioxidant network.- Membrane Transport Proteins.- The molecular basis for pleiotropic drug resistance in the yeast Saccharomyces cerevisiae: regulation of expression, intracellular trafficking and proteolytic turnover of ATP binding cassette (ABC) multidrug resistance transporters.- Regulation of carbon metabolism in bacteria.

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