Overview

Wilma Wasco and Rudolph Tanzi bring together the best and latest thinking by leading scientists on the etiologic and pathogenic events responsible for the onset of Alzheimer's disease and related dementias. In presenting the various mechanisms and multifaceted approaches currently being employed, the distinguished contributors review such critical factors as apoptosis, energy metabolism, excitotoxicity and calcium-mediated cell death, free radicals, electrophysiological abnormalities, environmental toxins, degeneration of neural networks, and modification of the cytoskeleton. They also examine mechanisms by which ischemia and hypoxia result in dementia. The book provides critical insights into the necessary direction of future investigations of dementia.

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9780896033719

Table of Contents

Reviews

In conclusion, the first chapters of this book provide a lot of very recent information related to the production and the toxicity of the amyloid peptide as well as to the possible role of new genes involved in Alzheimer's disease. It represents a very interesting review for scientists studying the cellular and molecular mechanisms involved in the neurodegeneration of Alzheimer's disease.-ACTA Neurologica Belgica The text is logically organized, which helps in making a transition from one subject to the other. The topics are well selected; classical, and new, often controversial, research is covered. Each chapter is succinct and ends with an informative summary...this expertly written overview also provides directions for future studies...a valuable reference and source of inspiration. It is highly recommended to all interested in the molecular basis of neurodegenerative diseases. -Cell Biology International

In conclusion, the first chapters of this book provide a lot of very recent information related to the production and the toxicity of the amyloid peptide as well as to the possible role of new genes involved in Alzheimer's disease. It represents a very interesting review for scientists studying the cellular and molecular mechanisms involved in the neurodegeneration of Alzheimer's disease.-ACTA Neurologica Belgica The text is logically organized, which helps in making a transition from one subject to the other. The topics are well selected; classical, and new, often controversial, research is covered. Each chapter is succinct and ends with an informative summary...this expertly written overview also provides directions for future studies...a valuable reference and source of inspiration. It is highly recommended to all interested in the molecular basis of neurodegenerative diseases. -Cell Biology International

"In conclusion, the first chapters of this book provide a lot of very recent information related to the production and the toxicity of the amyloid peptide as well as to the possible role of new genes involved in Alzheimer's disease. It represents a very interesting review for scientists studying the cellular and molecular mechanisms involved in the neurodegeneration of Alzheimer's disease.-ACTA Neurologica Belgica ""The text is logically organized, which helps in making a transition from one subject to the other. The topics are well selected; classical, and new, often controversial, research is covered. Each chapter is succinct and ends with an informative summary...this expertly written overview also provides directions for future studies...a valuable reference and source of inspiration. It is highly recommended to all interested in the molecular basis of neurodegenerative diseases.""-Cell Biology International"

In conclusion, the first chapters of this book provide a lot of very recent information related to the production and the toxicity of the amyloid peptide as well as to the possible role of new genes involved in Alzheimer's disease. It represents a very interesting review for scientists studying the cellular and molecular mechanisms involved in the neurodegeneration of Alzheimer's disease.-ACTA Neurologica Belgica The text is logically organized, which helps in making a transition from one subject to the other. The topics are well selected; classical, and new, often controversial, research is covered. Each chapter is succinct and ends with an informative summary...this expertly written overview also provides directions for future studies...a valuable reference and source of inspiration. It is highly recommended to all interested in the molecular basis of neurodegenerative diseases. -Cell Biology International

In conclusion, the first chapters of this book provide a lot of very recent information related to the production and the toxicity of the amyloid peptide as well as to the possible role of new genes involved in Alzheimer's disease. It represents a very interesting review for scientists studying the cellular and molecular mechanisms involved in the neurodegeneration of Alzheimer's disease. - ACTA Neurologica Belgica The text is logically organized, which helps in making a transition from one subject to the other. The topics are well selected; classical, and new, often controversial, research is covered. Each chapter is succinct and ends with an informative summary this expertly written overview also provides directions for future studies a valuable reference and source of inspiration. It is highly recommended to all interested in the molecular basis of neurodegenerative diseases. - Cell Biology International

In conclusion, the first chapters of this book provide a lot of very recent information related to the production and the toxicity of the amyloid peptide as well as to the possible role of new genes involved in Alzheimer's disease. It represents a very interesting review for scientists studying the cellular and molecular mechanisms involved in the neurodegeneration of Alzheimer's disease.-ACTA Neurologica Belgica ""The text is logically organized, which helps in making a transition from one subject to the other. The topics are well selected; classical, and new, often controversial, research is covered. Each chapter is succinct and ends with an informative summary...this expertly written overview also provides directions for future studies...a valuable reference and source of inspiration. It is highly recommended to all interested in the molecular basis of neurodegenerative diseases.""-Cell Biology International

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