Overview

Providing up-to-date information on the major histocompatibility complex in the different vertebrate classes from fishes to mammals, this text also brings together two fields of research - immunogenetics and evolutionary biology. Topics covered include the nature of Mhc varibility; the manner of Mhc evolution; the importance of Mhc for understanding human evolution; and the interpretation of Mhc polymorphism.

Full Product Details

Author:   Jan de Klein ,  Dagmar Klein
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   59
Weight:   0.995kg
ISBN:  

9783540546085

ISBN 10:   3540546081
Pages:   522
Publication Date:   06 December 1991
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Organization and evolution of the MHC chromosomal region: An overview.- Reconstruction of phylogenetic trees and evolution of major histocompatibility complex genes.- Trans-species polymorphism of HLA molecules, founder principle, and human evolution.- Calibrating evolutionary rates at major histocompatibility complex loci.- Concerted mutagenesis: Its potential impact on interpretation of evolutionary relationships.- Two models of evolution of the class I MHC.- Evolution of MHC domains: Strategy for isolation of MHC genes from primitive animals.- Generation of allelic polymorphism at the DRB1 locus of primates by exchange of polymorphic domains: A plausible hypothesis?.- A phylogenetic investigation of MHC class II DRB genes reveals convergent evolution in the antigen binding site.- Diversification of class II A? within the genus Mus.- Molecular and genetic mechanisms involved in the generation of Mhc diversity.- Evidence for multiple mutational mechanisms which generate polymorphism at H-2K.- Contributions of interlocus exchange to the structural diversity of the H-2K, D, and L alleles.- Evolution of Great Ape MHC class I genes.- Evolution of New World primate MHC class I genes.- Polymorphisms of the major histocompatibility complex in Old and New World primates.- Mhc class I genes of New World monkeys and their relationship to human genes.- Selective inactivation of the primate Mhc-DQA2 locus.- Is DQB2 functional among nonhuman primates?.- Alu repeats and evolution of the HLA-DQA1 locus.- The Alu repeats of the primate DRB genes.- Interpreting MHC disequilibrium.- Frozen haplotypes in Mhc evolution.- The age and evolution of the DRB pseudogenes.- Organization and evolution of the HLA-DRB genes.- The MHC of Peromyscus Leucopus (Mhc-Pele) illustrates large- and small-scale expansion in the phylogeny of MHC loci.- Sequence and evolution of bovine MHC class I genes.- Evolution of MHC molecules in nonmammalian vertebrates.- The polymorphic B-G antigens of the chicken MHC - Do the structure and tissue distribution suggest a function?.- Evolution of primate C4 and CYP21 genes.- Mapping of a hot spot in the major recombination area of the mouse H-2 complex.- Conservation versus polymorphism of the MHC in relation to transplantation, immune responses, and autoimmune disease.- HLA associations with malaria in Africa: Some implications for MHC evolution.- The evolution of MHC-based mating preferences in Mus.- Possible MHC associated heterozygous advantage in wild mouse populations.- Antigen presentation by neoclassical MHC class I gene products in murine rodents.- Mls antigens (superantigens), class II MHC, and Tcr repertoire: Co-adaptive evolution.- Diversity and evolution at the Eb recombinational hotspot in the mouse.- Molecular dissection of the Eb recombinational hotspot in the mouse.- Molecular cloning of nurse shark cDNAs with high sequence similarity to nucleoside diphosphate kinase genes.- Author Index.

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