Overview

Present and potential future applications of new diagnostic strategies based on the direct or indirect detection of cancer genes are delineated in this volume. Among the methodological aspects covered are enzymatic target amplification by the polymerase chain reaction and related techniques, DNA fingerprinting, transfer of putative cancer genes in appropriate recipient cells, and recent developments in the application of monoclonal antibodies in immunohistochemistry and immunoscintigraphy. The diagnostic and functional implications of mutations in cancer genes such as ras and p53 are also described.

Full Product Details

Author:   Christoph Wagener ,  Siegfried Neumann
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   1993 ed.
Dimensions:   Width: 15.50cm , Height: 1.30cm , Length: 23.50cm
Weight:   0.375kg
ISBN:  

9783540554769

ISBN 10:   3540554769
Pages:   223
Publication Date:   04 December 1992
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

The Polymerase Chain Reaction: Methodology and Diagnostic Potential.- Gene Loss as Marker in Tumor Development: Considerations on the Origin of Specific Brain Tumors Due to Combinant Loss of Function Mutations of Tumor Suppressor Genes.- p53: Oncogene, Tumor Suppressor, or Both?.- Tumor Genome Screening by Multilocus DNA Fingerprints as Obtained by Simple Repetitive Oligonucleotide Probes.- Activation of ras Oncogenes in Human Tumours.- Laboratory Techniques in the Investigation of Human Papillomavirus Infection.- Detection of Minimal Residual Leukemia by Polymerase Chain Reactions.- A Dominant Metastogene Confers Metastatic Potential to Tumor Cells.- Progression in Human Melanoma Is Accompanied by the Altered Expression of Cell Adhesion Molecules.- Structure, Function and Expression of the CEA Gene Family: Diagnostic and Therapeutic Implications.- Membrane Proteins as Markers for Normal and Neoplastic Endocrine Cells.- Biological and Clinical Relevance of the Tumor-Associated Serine Protease uPA.- Analysis of Growth Regulatory Pathways in Human Neuro-Oncology.- HER-2/Neu/c-ERB-B2 Amplification: Clinical Relevance in Mammary Carcinoma.- Cytokine-Mediated Regulation of Growth Factor Receptors (EGF-R and erb-B2) in Pancreatic Tumors.- Chimeric CEA-Specific Antibody Fragments and Anti-idiotypic Antibodies for Immunoscintigraphy and New Therapeutic Approaches to Colorectal Carcinomas.- Tumor Localization by Immunoscintigraphy: Potential and Limitations.

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