Overview

These comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake.

Full Product Details

Author:   Boris Draznin ,  Derek LeRoith
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1994 ed.
Dimensions:   Width: 15.20cm , Height: 2.30cm , Length: 22.90cm
Weight:   0.774kg
ISBN:  

9780896032866

ISBN 10:   0896032868
Pages:   404
Publication Date:   02 September 1994
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Molecular Mechanisms of Autoimmunity and Genetics of Diabetes.- 1. Molecular Targets of the Autoimmunity of Type I Diabetes.- 2. Murine Transgenic Models of IDDM.- 3. Pancreatic Islet Transplantation.- 4. Pathogenesis of Autoimmune Diabetes.- Molecular and Cellular Aspects of Insulin Synthesis and Secretion.- 5. Insulin Gene Structure and Regulation.- 6. Molecular Engineering of Glucose-Regulated Insulin Secretion.- 7. Glucokinase Gene Expression and Regulation.- 8. Fundamentals of Fuel Sensing and Intermediary Metabolism in Pancreatic A-and B-Cells.- 9. Glucose Toxicity and the Insulin Gene.- 10. Proinsulin-Processing Endopeptidases.- 11. GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis.- 12. ?-Cell Receptors: Mechanisms of Signal Transduction.- 13. Molecular Biology of the Ion Channels in the Pancreatic ?-Cell.- 14. Molecular Biology of Gap Junction Proteins.- 15. The Gluco-Incretin Hormone Glucagon-Like Peptide-1 and Its ?-Cell Receptor.- 16. Islet Amyloid Polypeptide (IAPP) and Insulin Secretion.

Reviews

This is an essential book for a medical library to have, and it is a welcome addition to the library of investigators in the field. Specialists in diabetes will also find this book very useful. - Kevan Herold, MD for Doody's Health Science Book Review Journal

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