Overview

V(D)J recombination and heavy chain gene class switching constitute two major DNA recombination processes, complemented by somatic hypermutation, which generate the antigen receptor repertoire of the immune system. This volume offers an overview of these processes. The advances in these areas include the identification of several individual proteins acting at the initial steps in V(D)J recombination, and detailed insights into the formation and structure of recombination intermediates. The book also includes a description of the third mechanism for increasing the antigen receptor diversity somatic hypermutation which has attracted renewed sttention.

Full Product Details

Author:   Rolf Jessberger ,  Michael R. Lieber
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v.217
Weight:   0.490kg
ISBN:  

9783540610373

ISBN 10:   3540610375
Pages:   233
Publication Date:   16 July 1996
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Initiation of V(D)J Recombination in a Cell-Free Systenn by RAG1 and RAG2 Proteins.- rag-1 and rag-2: Biochemistry and Protein Interactions.- Regulation of Recombination Activating Gene Expression During Lymphocyte Development.- The Cell Cycle and V(D)J Recombination.- Double-Strand Breaks, DNA Hairpins, and the Mechanism of V(D)J Recombination.- Identification of the Catalytic Subunit of DNA Dependent Protein Kinase as the Product of the Mouse scid Gene.- The DNA-Activated Protein Kinase - DNA-PK.- Role of the Ku Autoantigen in V(D)J Recombination and Double-Strand Break Repair.- Characterization of Chinese Hamster Cell Lines That Are X-Ray-Sensitive, Impaired in DNA Double-Strand Break Repair and Defective for V(D)J Recombination.- Identification of the XRCC4 Gene: Complementation of the DSBR and V(D)J Recombination Defects of XR-1 Cells.- Developmental and Molecular Regulation of Immunoglobulin Class Switch Recombination.- Transcription Targets Recombination at Immunoglobulin Switch Sequences in a Strand-Specific Manner.- Biochemical Studies of Class Switch Recombination.- Somatic Hypermutability.

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