Overview

This is Section B of the ""Manual of Biological Markers of Disease"". It contains information on more than 20 autoantigens related to important autoimmune connective tissue diseases such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis and others. For every autoantigen, there are well annotated sections with detailed and complete information on detection methods, cellular localization, biochemical characteristics, function, cDNA and derived amino acid sequence, gene structure, B and T-cell epitopes and a list of available monoclonal antibodies. The chapters are all structured according to an easy-reference fixed template. The text is greatly enhanced by many schematic figures. After the initial purchase, the publisher will send the reader a supplement upon publication, together with an invoice, until such time as they are notified otherwise. The Manual of Section A and B is an authoritative compilation of methods for the detection of autoantibodies (Section A; Fall 1993); the structure, function and molecular and biochemical concepts of autoantigens (Section B; Spring 1994); and the clinical importance of measuring autoantibodies in patients with rheumatic, connective tissue and autoimmune diseases (Section C; 1994). Contributors include leading experts in the immunological, molecular biological and clinical fields. The format of this looseleaf publication allows regular updating of data as well as inclusion of new advances in research on autoimmunity. After Section C, Supplements to Sections B and C will be published with full information on autoantigens implicated in other autoimmune diseases such as diabetes mellitus and autoimmune thyroid and liver diseases. It is further intended to enlarge the scope of the Manual to include additional sections on other biological markers of arthritis and connective tissue diseases. This Manual should prove a useful text and reference book for bench scientists working in the field of autoimmunity, but also for rheumatologists, general (internal medicine) physicians or clinical immunologists caring for patients with autoimmune disorders.

Full Product Details

Author:   W.J. van Venrooij (Department of Biochemistry, University of Nijmegen, The Netherlands) ,  Ravinder Maini
Publisher:   Kluwer Academic Publishers
Imprint:   Kluwer Academic Publishers
Edition:   Annotated edition
Weight:   0.723kg
ISBN:  

9780792327714

ISBN 10:   0792327713
Pages:   360
Publication Date:   01 September 1994
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Loose-leaf
Publisher's Status:   Out of Stock Indefinitely
Availability:   Out of stock  

Table of Contents

Section A: Methods of Autoantibody Detection. Introduction; W.J. van Venrooij, R.N. Maini. International cooperative activities in standardization of antinuclear antibodies; E.M. Tan. Detection of antinuclear antibodies by immunofluorescence; R.L. Humbel. Counterimmunoelectrophoresis and immunodiffusion for the detection of antibodies to soluble cellular antigens; C. Bunn, T. Kveder. Protein blotting; R. Verheijen, M. Salden, W.J. van Venrooij. Enzyme-linked immunosorbant assay in the rheumatological laboratory; P.J. Charles, R.N. Maini. Immunoprecipitation of labelled proteins; E.M. Tan, C.L. Peebles. Analysis of autoimmune sera by immunoprecipitation of cellular RNPs; G. Zieve, M. Fury, E.J.R. Jansen. Measurement of antibodies to DNA; R. Smeenk. Methods to detect autoantibodies to neutrophilic granulocytes; A. Wiik, N. Rasmussen, J. Wieslander. Detection of antiperinuclear factor and antikeratin antibodies; R.M.A. Hoet. Standards and reference preparations; T.E.W. Feltkamp. Section B: Autoantigens. Introduction; W.J. van Venrooij, R.N. Maini. Autoantigens in rheumatoid arthritis (RA). RF (rheumatoid factor); R.A. Mageed. APF (antiperinuclear factor); J.-M. Berthelot, C. Vincent, G. Serre, P. Youinou. RA-33 (hnRNP-A2); G. Steiner. Collagen II; D.G. Williams. Autoantigens in systemic Lupus erythematosus (SLE). DNA; R.J.T. Smeenk. Histones; R.W. Burlingame, R.L. Rubin. Ubiquitin; S. Muller. Sm; S.O. Hoch. Ribosomal RNP; K.B. Elkon. Ku; W.H. Reeves, M. Satoh, J. Wang, A.K. Ajmani. PCNA; Y. Muro, E.M. Tan. Phospholipids; E.N. Harris. Autoantigens in SLE-overlap syndromes. The U1 snRNP complex; J.M.T. Klein Gunnewiek, W.J. van Venrooij. Autoantigens in Sjogren's syndrome. R0/SS-A; E.K.L. Chan, J.P. Buyon. La/SS-B; G.J.M. Pruijn. Autoantigens in Scleroderma. DNA topoisomerase 1; R. Verheijen. Centromere proteins; P. Verheijen. Fibrillarin; R. Verheijen. PM/Scl; F.A. Bautz, M. Bluhtner. Autoantigens in Myositis. Transfer RNA synthetases; P. Plotz, I.N. Targoff. Autoantigens in Vasculitis. Proteinase 3 (c-ANCA); J. Wieslander, A. Wiik. Myeloperoxidase (MPO); J. Wieslander, A. Wiik. Autoantigens in other diseases. Mitochondrial autoantigens; P.S.C. Leung, I. Mackay, M.E. Gershwin. P80 coilin; M. Carmo-Fonseca, K. Bohmann, M.T. Carvalho, A.I. Lamond.

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