Overview

"""In situ"" hybridization is a technique of molecular biology that is used to localize the genetic machinery (genes) involved in protein production, by the use of complimentary strands of genetic material (oligonucleotides of DNA or RNA). It is important in the study of the mechanisms underlying cellular function and disease. This book covers all aspects of ""in situ"" hybridization, from the basic principles of molecular biology, through the various methodological advances, to its most up-to-date applications in pathology."

Full Product Details

Author:   Julia M. Polak ,  James O'D. McGee
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 16.00cm , Height: 1.90cm , Length: 23.00cm
Weight:   0.610kg
ISBN:  

9780192619068

ISBN 10:   0192619063
Pages:   260
Publication Date:   01 May 1990
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Replaced By:   9780198548805
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

"Basic background of molecular biology, V.T-W.Chan et al; principles of ""in situ"" hybridization, H.Hofler; radioactive labels - autoradiography and choice of emulsions for ""in situ"" hybridization, M.A.W.Brady and M.A.Finlan; non-radioactive probes - preparation, characterization, and detection, V.T-W.Chan and J.O'D.McGee; oligonucleotide probes for ""in situ"" hybridization, R.Lathe; principles and applications of complementary RNA probes, S.J.Gibson and J.M.Polak; quantification of radioactive ""in situ"" hybridization signals, A.P.Davenport and D.J.Nunez; ""in situ"" hybridization and the study of development, D.G.Wilkinson; ""in situ"" hybridization in virology, C.G.Teo; chromosomal assignment of genes, B.Bhatt and J.O'D.McGee; interphase cytogenetics of solid tumours, A.H.N.Hopman et al; single and simultaneous nucleic acid detection in archival human biopsies - application of non-isotopic ""in situ' hybridization and the polymerase chain reaction to the analysis of human and viral genes, C.S.Herrington et al; photomicrography, S.Bradbury."

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