Overview

Immunological Aspects of Preterm Birth: Phenotypes of Preterm Birth, Immune Mechanisms, and Pathway Forward bridges reproductive immunology of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. The book reviews the role of the different immune mechanisms during pregnancy that lead to preterm birth, along with the fetal programming effects that are connected to maternal immune activation. In addition, it discusses immune cells and their products and cytokines and chemokines as central for the success of the pregnancy. While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentially in the last 10 years, connecting basic science to clinical science and the development of new therapeutics has not progressed as rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processes associated with preterm birth and fills an urgent need for the development of therapeutics in this space.

Full Product Details

Author:   Irina Burd MD (Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland, Maryland, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.450kg
ISBN:  

9780443215643

ISBN 10:   0443215642
Pages:   536
Publication Date:   27 March 2026
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

1. Preterm labor, preterm birth and prematurity: Molecular and clinical phenotypes 2. Screening, diagnosis and therapeutic approaches to preterm labor 3. Potential use of biomarkers as therapeutic targets of immunotherapy in preterm birth 4. Fetal and placental inflammation in preterm birth 5. Innate Immunity: the role of macrophages and beyond 6. The role of T cells and other adaptive immune mediators in preterm birth 7. Spontaneous preterm birth: Immunoperinatology perspective 8. Fetal pathophysiological changes in preterm birth 9. Vaginal microbiome and preterm birth 10. Viral infections and preterm birth 11. Environment-immune interactions and epigenetics in preterm birth 12. Special considerations: Pregnancy and organ transplantation 13. Placenta: Window into neonatal health 14. Neonatal outcomes following preterm birth 15. Spontaneous preterm birth: Current therapies and opportunities for the future 16. Pathway forward

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Author Information

Irina Burd, MD, PhD, is a renowned maternal–fetal medicine and reproductive immunology expert. She is the Sylvan Frieman, M.D. Endowed Professor and Chair of Obstetrics, Gynecology and Reproductive Sciences at the University of Maryland School of Medicine, leading initiatives in women’s health research, clinical care and education. Her research explores immunology, pregnancy, and fetal development, focusing on placental inflammation and infection and their effects on neonatal and long-term outcomes. With over 170 peer-reviewed publications, her work has been funded by NIH and other organizations, advancing understanding of the maternal–fetal immune interface. A dedicated educator and mentor, she has trained numerous clinicians, clinician-scientists and scientists. Dr. Burd has held leadership roles in prominent organizations, fostering collaboration in women’s health. Her work continues to shape perinatal medicine, aiming to improve outcomes for mothers and children worldwide.

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