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OverviewKey Features * Explores evolutionary context and comparative physiology of hypoxia tolerance in fetus and neonate, from basic research to clinical scenarios * Provides guidance to trainees, physicians and allied health professionals engaged in NICU care; pediatricians, cardiologists, pulmonologists, anesthesiologists, neonatologists and physiologists, to effectively manage infants in hypoxic respiratory failure * Includes case scenarios emphasizing current diagnostic and therapeutic controversies, and algorithmic approaches to decipher difficult clinical cases. Full Product DetailsAuthor: Shyamala Dakshinamurti (University of Manitoba, Canada) , Steven H. Abman , Po-Yin Cheung , Satyan LakshminrusimhaPublisher: Taylor & Francis Ltd Imprint: CRC Press Weight: 0.660kg ISBN: 9780367493998ISBN 10: 0367493993 Pages: 254 Publication Date: 29 October 2021 Audience: College/higher education , Professional and scholarly , Tertiary & Higher Education , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsTable of Contents 1. Introduction Part 1: The Origins of Hypoxia Tolerance 2. The Human Fetus and Metabolic Adaptations to Hypoxia 3. Hypoxia as a Neuroinflammatory Stimulus During Development 4. Human Adaptations to High Altitude 5. Fetal Llama Adaptation to Altitude in the Andean Altiplano 6. Neonates of Burrowing and Hibernating Mammals: Metabolic and Respiratory Adaptations to Hypoxia 7. Diving Response and Hypoxia in Deep Sea Mammals 8. The Phylogeny and Ontogeny of Cardiorespiratory Coupling in Vertebrates and its Relevance to Non-Invasive Monitoring of the Human Fetus Part 2: Fetal Hypoxia and Neonatal Transition 9. Fetal and Neonatal Oxygen Environment 10. Fetal Oxygenation During Maternal Hypoxic Illness 11. Hemodynamics of the Circulatory Transition 12. Oxygen During Postnatal Stabilization Part 3: Biology of Hypoxic Respiratory Failure in the Neonate 13. Hypoxia and Pulmonary Artery Structure 14. Animal Models of PPHN and Vasoconstrictor Signaling in Hypoxia 15. Hypoxia and Endothelial Dysfunction in the Lung 16. Effects of Hypoxia on Pulmonary Vascular Smooth Muscle Contraction and Relaxation 17. Cellular Oxygen Sensing, Mitochondrial Oxygen Sensing and Reactive Oxygen Species 18. Reactive Oxygen Species Signaling in Animal Models of Pulmonary Hypertension 19. Hypoxia, Myocardial Metabolic Adaptation and Right Ventricular Performance 20. Hypoxic Remodeling of Neonatal Pulmonary Artery and Myocardium 21. Hypoxia-Induced Epigenetic Mechanisms of Pulmonary Hypertension Part 4: Hypoxia and Collateral Damage 22. The Effects of Hypoxia Ischemia on the Term Brain, and A Strategic Approach 23. Effects of Hypoxia on Cerebral Perfusion and the Blood-Brain Barrier 24. Effects of Hypoxia on Airway, Alveolar Function and Respiration 25. Hypoxic Respiratory Failure and the Neonatal Kidney 26. The Effect of Hypoxia on Intestinal Function 27. Effects of Hypoxia on Perinatal Drug Disposition 28. Anesthetic Considerations for the Neonate with Hypoxic Respiratory Failure Part 5: Diagnosis and Management of Neonatal Hypoxic Respiratory Failure 29. Epidemiology and Outcomes of Infants with Hypoxemic Respiratory Failure 30. Clinical Evaluation of Hypoxic Respiratory Failure 31. Diagnosis of Pulmonary Hypertension by Echocardiography 32. Right Ventricular Performance and Ventricular Interdependence in Hypoxia 33. Ventilation Strategies in Neonatal Hypoxemic Respiratory Failure 34. Pulmonary Hypertension Phenotypes in the Newborn 35. Special Consideration: HRF in Congenital Diaphragmatic Hernia 36. Special Consideration: Hypoxemic Respiratory Failure Among Patients with Hypoxic Ischemic Encephalopathy 37. Special Consideration: HRF in the Preterm 38. Hypoxemic Respiratory Failure - Neonatal CasesReviewsThis book elects to follow the thread of hypoxia, as an originating etiology and defining feature of neonatal pulmonary hypertension. It is a comprehensive and thematic volume of topical articles by world renowned authors, and has assembled all information pertinent to this topic in 38 chapters divided into 5 distinct sections, each marshalled by a dedicated co-editor. This strong interdisciplinary editorial team brings to bear complementary theoretical and practical expertise in different aspects of hypoxia and respiratory failure, and clearly a wide-ranging contact list - the book has over 80 contributing authors. Salient features of this book are helpful signaling pathway diagrams, conceptual illustrations, and synthesis figures by Satyan Lakshminrusimha. Reading the whole volume provides a satisfying continuous narrative of hypoxia through the evolutionary and developmental timeline, and deeper insight into what might appear to be only a superficial problem solved by turning up the oxygen dial. This book is therefore recommended to practicing clinicians as much as to scholars in this field of science. Dr Kurt Stenmark Author InformationEditor Dr Shyamala Dakshinamurti is a neonatologist and biomedical researcher, Professor of Pediatrics and Physiology at the University of Manitoba, Canada, and member of the Biology of Breathing theme, Children's Hospital Research Institute of Manitoba. Section Editors Dr Steven H. Abman is Professor of Pediatrics and Director of the Pediatric Heart Lung Center at the University of Colorado Anschutz School of Medicine and the Children's Hospital Colorado, USA. Dr Po-Yin Cheung is a neonatologist of the Northern Alberta Neonatal Program of Alberta Health Services and Professor in the Departments of Pediatrics, Pharmacology and Surgery at the University of Alberta, Canada. Dr Satyan Lakshminrusimha is a neonatologist and the Dennis and Nancy Marks Chair and Professor of Pediatrics at the University of California at Davis, Sacramento, USA. Dr Patrick McNamara is a staff neonatologist and Director of the Division of Neonatology at the University of Iowa Stead Family Children's Hospital and Professor of Pediatrics and Internal Medicine, University of Iowa, USA. Dr William K. Milsom is a comparative physiologist and Emeritus Professor of Zoology at the University of British Columbia, Canada. Tab Content 6Author Website:Countries AvailableAll regions |
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