Overview
Histone Deacetylases in Neurodegenerative Disease, Part A, Volume 733 in the Methods in Enzymology series, highlights new advances, with this volume presenting chapters on topics such as HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress, Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticity, Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis, Histone Deacetylase 6 modulates Tau structure and function, Histone Acetylation in Parkinson Disease, DNA methylation and histone modification in hypoxic conditions, The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cells, Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimer's disease, and much more. Additional chapters explore Sirtunins in mitochondrial physiology and energy homeostasis, Sirtunins in metabolic homeostasis, Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4, Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channel, Histone deacetylase as a potential therapeutic target for memory disorders, Histone deacetylases in Neurodegeneration, Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer’s Disease, Histone deacetylases in Neurodegeneration and neuronal plasticity, and more.
Full Product Details
Author: David Christianson (University of Pennsylvania, USA) ,
Karen N. Allen (Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston, MA, USA) ,
Subashchandrabose Chinnathambi, PhD (Additional Professor, Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India)
Publisher: Elsevier Science Publishing Co Inc
Imprint: Academic Press Inc
Weight: 0.450kg
ISBN: 9780443473326
ISBN 10: 0443473323
Pages: 258
Publication Date: 01 September 2026
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Forthcoming
Availability: Not yet available
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.
Author Information
After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015. Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering Subashchandrabose Chinnathambi is Additional Professor at the Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India. His scientific interests include physiopathology of neurodegenerative disorders, Tau Cytoskeleton, Tau-GPCR, purinergic and chemokine receptors, Tau stem cells, animal models, neuropharmacology, therapeutic approaches targeting Tau oligomers, and biomarkers for neurodegeneration. He serves on the editorial board for various international cell biology journals and is also a regular invited speaker at a number of meetings and workshops. Dr. Chinnathambi has more than 16 years of research experience in the area of neuroscience and Tau-related research in Alzheimer’s Disease.
