Overview
This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give readers a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. This is a useful handbook for frontline researchers as well as a textbook for advanced students. Besides comprehensive cover of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry. The reports include in vitro studies of the motility of reconstituted complexes and in vivo studies of organisms expressing mutant dyneins. The recent technical improvements described, which have played an important part in recent advances, include the expression and preparation of recombinant dynein heavy chains or individual subdomains.
Full Product Details
Author: Keiko Hirose ,
Linda A. Amos (MRC Laboratory of Molecular Biology, Cambridge, UK)
Publisher: Pan Stanford Publishing Pte Ltd
Imprint: Pan Stanford Publishing Pte Ltd
Dimensions:
Width: 15.20cm
, Height: 2.50cm
, Length: 22.90cm
Weight: 0.680kg
ISBN: 9789814303330
ISBN 10: 981430333
Pages: 404
Publication Date: 22 February 2012
Audience:
Professional and scholarly
,
Professional & Vocational
Replaced By: 9789814800013
Format: Hardback
Publisher's Status: Active
Availability: Awaiting stock
The supplier is currently out of stock of this item. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out for you.
Reviews
Given the recent explosion of interest in dynein, this book gives a timely review of both historical and current developments in the field. It is an extensive compendium compiled by leading dynein researchers and an excellent resource for young and experienced scientists alike! Prof. Joe Howard, Max Planck Institute of Molecular Cell Biology and Genetics, Germany Handbook of Dynein, edited by the eminent electron microscopists Keiko Hirose and Linda Amos and contributed to by many international leading scientists in the field, is an excellent introduction to cutting-edge dynein research, including such aspects as biochemistry, molecular biology, biophysics, structural biology, and molecular genetics. It introduces not only the mechanisms of how cilia and flagella move and how the intracellular transport is performed by dyneins but also the pathogenesis of diseases related to the dynein motor complex. Thus, it will be a really fine handbook for students and researchers in the broad areas of life sciences. Prof. Nobutaka Hirokawa, University of Tokyo, Japan
Given the recent explosion of interest in dynein, this book gives a timely review of both historical and current developments in the field. It is an extensive compendium compiled by leading dynein researchers and an excellent resource for young and experienced scientists alike! -Prof. Joe Howard, Max Planck Institute of Molecular Cell Biology and Genetics, Germany Handbook of Dynein, edited by the eminent electron microscopists Keiko Hirose and Linda Amos and contributed to by many international leading scientists in the field, is an excellent introduction to cutting-edge dynein research, including such aspects as biochemistry, molecular biology, biophysics, structural biology, and molecular genetics. It introduces not only the mechanisms of how cilia and flagella move and how the intracellular transport is performed by dyneins but also the pathogenesis of diseases related to the dynein motor complex. Thus, it will be a really fine handbook for students and researchers in the broad areas of life sciences. -Prof. Nobutaka Hirokawa, University of Tokyo, Japan
Given the recent explosion of interest in dynein, this book gives a timely review of both historical and current developments in the field. It is an extensive compendium compiled by leading dynein researchers and an excellent resource for young and experienced scientists alike! -Prof. Joe Howard, Max Planck Institute of Molecular Cell Biology and Genetics, Germany Handbook of Dynein, edited by the eminent electron microscopists Keiko Hirose and Linda Amos and contributed to by many international leading scientists in the field, is an excellent introduction to cutting-edge dynein research, including such aspects as biochemistry, molecular biology, biophysics, structural biology, and molecular genetics. It introduces not only the mechanisms of how cilia and flagella move and how the intracellular transport is performed by dyneins but also the pathogenesis of diseases related to the dynein motor complex. Thus, it will be a really fine handbook for students and researchers in the broad areas of life sciences. -Prof. Nobutaka Hirokawa, University of Tokyo, Japan
Author Information
Keiko Hirose is Senior Research Scientist at the National Institute of Advanced Industrial Science and Technology in Japan. Linda A. Amos is Group Leader at the MRC Laboratory of Molecular Biology in Cambridge, UK.
