Overview

This collection of robust, readily reproducible methods for microarray-based studies includes expert guidance in the optimal data analysis and informatics. On the methods side are proven techniques for monitoring subcellular RNA localization en masse, for mapping chromosomes at the resolution of a single gene, and for surveying the steady-state genome-wide distribution of DNA binding proteins in vivo. For those workers dealing with massive data sets, the book discusses the methodological aspects of data analysis and informatics in the design of microarray experiments, the choice of test statistic, and the assessment of observational significance, data reduction, and clustering.

Full Product Details

Author:   Michael J. Brownstein ,  Arkady Khodursky
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2003 ed.
Volume:   224
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   0.626kg
ISBN:  

9781588292919

ISBN 10:   1588292916
Pages:   260
Publication Date:   13 March 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Fabrication of cDNA Microarrays.- Nylon cDNA Expression Arrays.- Plastic Microarrays.- Preparing Fluorescent Probes for Microarray Studies.- Escherichia coli Spotted Double-Strand DNA Microarrays.- Isolation of Polysomal RNA for Microarray Analysis.- Parallel Analysis of Gene Copy Number and Expression Using cDNA Microarrays.- Genome-wide Mapping of Protein-DNA Interactions by Chromatin Immunoprecipitation and DNA Microarray Hybridization.- Statistical Issues in cDNA Microarray Data Analysis.- Experimental Design to Make the Most of Microarray Studies.- Statistical Methods for Identifying Differentially Expressed Genes in DNA Microarrays.- Detecting Stable Clusters Using Principal Component Analysis.- Clustering in Life Sciences.- A Primer on the Visualization of Microarray Data.- Microarray Databases.

Reviews

.,. .a good book, and it will be useful to microarray workers in their effots. - Journal of Chemical Neuroanatomy

"""....a good book, and it will be useful to microarray workers in their effots."" - Journal of Chemical Neuroanatomy"

...a good book, and it will be useful to microarray workers in their effots. - Journal of Chemical Neuroanatomy

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