Overview

The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function.  This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

Full Product Details

Author:   Fred W. Keeley ,  Robert Mecham
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2013 ed.
Dimensions:   Width: 15.50cm , Height: 1.70cm , Length: 23.50cm
Weight:   4.686kg
ISBN:  

9783642430374

ISBN 10:   3642430376
Pages:   290
Publication Date:   04 April 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Josephine C. Adams: Extracellular Matrix Evolution: An Overview.- Hiroshi Wada: Domain Shuffling and the Evolution of Vertebrate Extracellular Matrix.- Jean-Yves Exposito, Claire Lethias: Invertebrate and Vertebrate Collagens.- Fred. W. Keeley: The Evolution of Elastin.- Sacha Jensen, David Yadin, Ian Robertson, Penny Handford: Evolutionary Insights into Fibrillin Structure and Function in the Extracellular Matrix.- Fernando Segade: Molecular Evolution of the Microfibril-associated Proteins: The Fibulins and the MAGPs.- Cristina A. Baratta, Theodore J. Brown, Fahd Al-Dhalaan, Maurice J. Ringuette: Evolution and Function of SPARC and Tenascins: Matricellular Counter-adhesive Glycoproteins with Pleotropic Effects on Angiogenesis and Tissue Fibrosis.- David D. Roberts, William A. Frazier: Thrompospondins and their Receptors: Evolving Functions.- Mark S. Johnson, Jarmo Käpylä, Konstantin Denissiouk, Tomi Airenne, Bhanupratap Singh Chouhan, Jyrki Heino: Evolution of Cell Adhesion to Extracellular Matrix.

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