Overview

How is the epithelia organized? Which molecules mediate ion transport? How is an epithelia maintained? In this volume the authors discuss these and other key questions in the field and provide a clear guide to the methods used to answer them. The complexity of epithelial transport is reflected in the diverse approaches and methodologies used in its study. Written for active researchers, this book draws on the laboratory experience of leading investigators. An overview of the general principles underlying epithelial transport of ions, water and non-electrolytes is combined with guidance on practical approaches. The relative strengths and weaknesses of current methodologies are emphasized and potential pitfalls highlighted. This book should be of interest to graduates and researchers in cell biology, physiology, pharmacology, neurosciences and molecular biology.

Full Product Details

Author:   N.K. Wills ,  L. Reuss ,  S.A. Lewis
Publisher:   Chapman and Hall
Imprint:   Chapman and Hall
Edition:   1996 ed.
Dimensions:   Width: 15.60cm , Height: 2.20cm , Length: 23.40cm
Weight:   1.540kg
ISBN:  

9780412434006

ISBN 10:   0412434008
Pages:   356
Publication Date:   31 July 1996
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Epithelial structure and function.- 2 Epithelial transport proteins.- 3 Epithelial polarity.- 4 Characterization of epithelial ion transport.- 5 Epithelial electrophysiology.- 6 Impedance analysis of epithelia.- 7 Measurements and interpretation of cytoplasmic ion activities.- 8 Measurements of epithelial cell volume.- 9 Methods and experimental analysis of isolated epithelial cell membranes.- 10 Methods and experimental analysis of single ion channels.- 11 Epithelial cell culture.- 12 Signaling pathways regulating ion transport in polarized cells.- 13 The cytoskeleton and epithelial function.- 14 Future perspectives: molecular biology and pathophysiology.- Appendix A: Instrumentation.- Appendix B: Solving simple equivalent circuits.- Appendix C: A spread-sheet for marker distribution data.

Reviews

...it will certainly attract not only the undergraduate and graduate students, but also post-doctoral fellows and established investigators. We think it will be particularly useful for clinicians and dermatologists... - Cellular and Molecular Biology

...it will certainly attract not only the undergraduate and graduate students, but also post-doctoral fellows and established investigators. We think it will be particularly useful for clinicians and dermatologists... - Cellular and Molecular Biology

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