Overview
Epigenetic mechanisms are increasingly recognised as key contributors to neurodegenerative disease processes, shaping the molecular pathways involved in ageing, neuroinflammation and neuronal dysfunction. This volume provides an integrated overview of how DNA methylation, histone modifications, chromatin remodelling, non‑coding RNAs and epitranscriptomic regulation influence the onset and progression of neurodegenerative disorders. Covering a broad spectrum of conditions—including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, frontotemporal dementia, prion and prion‑like diseases, amyotrophic lateral sclerosis and multiple sclerosis—the book examines how epigenetic alterations interact with genetic, metabolic and environmental factors to drive disease pathology. Contributors detail advances in biomarker development, such as DNA methylation profiles, differentially methylated and hydroxymethylated regions, extracellular vesicles and neurofilament light chain, along with emerging therapeutic strategies involving CRISPR‑based epigenetic editing, histone deacetylase inhibitors and DNA methyltransferase inhibitors. Additional chapters explore cross‑disease themes including neuroinflammatory signalling, gut–brain epigenetic interactions, chromatin dynamics and ageing‑related epigenetic drift, offering insights into translational research and precision medicine. This volume serves as a valuable resource for researchers, clinicians and advanced students in neuroscience, molecular biology, genetics and biomedical sciences seeking to understand the role of reversible epigenetic regulation in neurodegenerative disorders.
Full Product Details
Author: Rasime Kalkan
Publisher: Springer Nature Switzerland AG
Imprint: Springer Nature Switzerland AG
ISBN: 9783032225771
ISBN 10: 3032225779
Pages: 542
Publication Date: 14 August 2026
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Forthcoming
Availability: Not yet available
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Author Information
Rasime Kalkan is a Professor of Medical Genetics at the European University of Lefke. Professor Rasime Kalkan completed her PhD in the Department of Medical Genetics at the Eskisehir Osmangazi University in Turkey. She served as a member of the Department of Medical Genetics at Near East University from November 2011 to June 2022. She served as Chair of the Department of Molecular Biology and Genetics in the Arts and Sciences Faculty at Near East University (2020–2022). She has been a member of the Turkish Medical Genetics Association since 2006. She worked on genetic and epigenetic alterations in brain tumours, especially in glioblastoma, during her PhD. She has edited books and journals, published numerous articles in peer-reviewed journals, and authored several chapters for various national and international books. She served as a project coordinator on many research projects. Her research is focused on the identification of epigenetic and genetic alterations in cancer, obesity, hypertension and post-menopausal term.
