Overview

Diabetes is a chronic disease and is a group of metabolic disorders characterized by hyperglycemia. More than 230 million people worldwide are affected, and it is expected to reach 350 million by 2025. Globally the affected people are unaware of the disease and only half receive adequate treatment . Diabetes is associated with long-term complications of peripheral nervous system and the central nervous system. Diabetic neuropathy is a common complication of diabetes that results in damage to the nerves due to high blood sugar levels for a long period of time. There are four types of diabetic neuropathy- peripheral, autonomic, proximal, and focal. In 2013, there were 65.1 million people between 20 and 79 years of age with diabetes in India and this number was predicted to rise to 109 million by 2035. The management of diabetes and its complications can be expensive, which poses serious obstacles to the strengthening of the Indian health care system and the Government's plan to achieve universal health coverage by 2022. Diabetic neuropathy (DN) is the most common change and complication that affect more than 50% of patients with diabetes. It is one of the leading causes of death in the world; thus, preventive measures are necessary for patients with diabetes from developing neuropathy. Allium cepa Lam. is a common and medicinally valuable plant. Leaves are reported to be aphrodisiac, anti-spasmodic, antihelmintic, alterative, carminative, digestive, diuretic, emollient, expectorant, mild laxative, stimulant and tonic along with presence of flavonoids27, Vitamin A, thiamin and ascorbic acid28. Outer layers of scales of its bulbs in different varieties were studied by researchers for their effects on chronic constriction injury induced neuropathic pain and resulted into significant antioxidant effect and improvement in neuropathic pain. Ficus carica Lam. belongs to order Urticales and family Moraceae. It is cultivated worldwide for its edible fruit. Fruits are a rich source of phenolic acids, vitamins, minerals, and organic acids. Conventionally, it has medicinal benefits for ailments of cardiovascular, respiratory, spasmodic, and inflammatory problems. Leaf extract has shown significant hypoglycemic effect

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