Overview

Computational structural biology has made tremendous progress over the last two decades, and this book provides a recent and broad overview of such computational methods in structural biology. It covers the impact of computational structural biology on protein structure prediction methods, macromolecular function and protein design, and key methods in drug discovery. It also addresses the computational challenges of experimental approaches in structural biology. In addition to reviewing the current state of computational structural biology, each chapter ends with a brief, visionary discussion on the future outlook, whereby the main challenges for the coming years are elucidated. Written by an international panel of expert contributors, this book can serve as a reference manual for students and practitioners alike.

Full Product Details

Author:   Torsten Schwede (Swiss Inst Of Bioinformatics & Biozentrum Of The Univ Of Basel, Switzerland) ,  Manuel C Peitsch (Novartis Inst For Biomedical Research, Switzerland)
Publisher:   World Scientific Publishing Co Pte Ltd
Imprint:   World Scientific Publishing Co Pte Ltd
Dimensions:   Width: 15.50cm , Height: 3.60cm , Length: 23.10cm
Weight:   1.293kg
ISBN:  

9789812778772

ISBN 10:   9812778772
Pages:   792
Publication Date:   06 May 2008
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Structure Prediction Methods: Protein Fold Recognition and Threading (L McGuffin); Assessment of Protein Structure Predictions (E Capriotti & M A Marti-Renom); From Structure to Function to Design: Evolution of Protein Folds (A Lupas & K Koretke); Molecular Modeling of Enzyme Reactions and Transition States (M Meuwly); Virtual Screening and Docking: MD-based Free Energy Simulations (O Michielin); Protein-Protein Interactions and Aggregation Processes (R Dima); New Frontiers in X-ray Crystallography (M Grutter); New Frontiers in Electron Microscopy (A Engel); Other Selected Topics: Docking for Neglected Diseases as Community Effort (M Provinec et al.); Protein Structure Databases (K Henrick et al.); Molecular Graphics (A M Lesk); and other chapters.

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