Overview

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T cells, B cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 1 of this two volume set discusses the immunobiology of chemokines. It is divided up into: cellular targets in innate and adaptive immunity, and effector cell traffic-unrelated functions. Volume 2 deals with the pathophysiology of chemokines, addressing in part 1 chemokines in animal disease models, and in part 2 chemokines as drug targets. Both volumes together give a comprehensive overview of chemokine biology.

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9786610969883

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