Overview

The International Study Group of Biological Thermodynamics, control and kinetics (BioThermoKinetics), is a loosely organized group of scientists that combines experimental and theoretical studies to enhance the understanding of cellular systems in which various molecular processes cooperate to produce physiology. The Study Group holds biannual conferences and organizes occasional schools. This book is an account of the most recent work by the group and contains an overview of recent developments in quantitative molecular biochemistry. Various topics are dealt with in short papers, which refer to primary papers for details. Their importance is indicated in the context of contemporary quantitative cell biochemistry.

Full Product Details

Author:   H.V. Westerhoff
Publisher:   Intercept Ltd
Imprint:   Intercept Ltd
ISBN:  

9780946707508

ISBN 10:   0946707502
Pages:   295
Publication Date:   01 July 1994
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Control of ketogenesis in human liver - quantitative analysis of the effect of alanine; the control of carbohydrate metabolism in the tapeworm Hymenolepis diminuta ; on the control of cell membrane expansion in higher plant protoplasts; futile cycling caused by the simultaneous presence of separate transport systems for uptake and secretion of amino acids in Corynebacterium glutamicum ; the experimental application of control analysis to metabolic systems; application of directed graphs and electrical analogues to metabolic control analysis; high sensitivity to effectors in metabolics cascades - a model for okadaic acid effects; control analysis of modular networks; determining several steady-state properties of biochemical systems in the case of incomplete knowledge of kinetic data; kinetic parameters of enzymes in states of maximal activity; control of proteoliposomal cytochrome c oxidase - models and mechanisms; cooperativity and coupling in cytochrome oxidase; the distinction between leaks and slips; kinetic control of cytochrome oxidase activity; age-dependent change in the redox proton pump intrinsic uncoupling; characterization of an outwardly directed reconstituted proton pump - the bacterial photosynthetic reaction centre; simulation of the kinetics of the H+-ATPase of the plasma membrane from yeast - kinetic investigations of the coupling of proton-flux and ATP-synthesis catalyzed by FoF1 ATP-synthases; uncoupling and slip in the Ca2+ -ATPase of sarcoplasmic reticulum; thermokinetics of Lac permease; kinetic mechanism of mannitol transport and the coupling of phosphorylation to transport catalyzed by the mannitol permease of Escherichia coli ; initial rate kinetic study of the pyruvate translocator in intact rat-heart mitochondria; application of a linear flow-force relationship to the bioenergic characterization of transient state phosphate uptake by the cyanobacterium Anacystis nidulans ; dynamics of the bacterial flagellar motor; chemotaxis and chemokinesis in Rhodobacter sphaeroides ; temporal self-organization and linear non-equilibrium thermodynamics are not mutually exclusive in autocatalytic systems; optimum efficiency of energy transformation, and catabolic-anabolic compartmentalization; a brief description of two computer programs, SCAMP and iMAP; METACON - a program for the algebraic evaluation of control coefficients of arbitrary metabolic networks; GEPASI - a simulator for the dynamical behaviour of biochemical pathways; control software for the analysis of the control of metabolic networks. (part contents)

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