Overview

This text is based on lecture courses given to undergraduates at Liverpool and Manchester Universities, and is intended as an introduction to the biochemistry of antimicrobial action for advanced students in many disciplines. The book is concerned with a discussion of medically important antimicrobial compounds and also a number of agents that, although having no medical uses, have proved themselves as research tools in biochemistry. The aim has been to present the available information in a simple and readable way, emphasizing the established facts rather than more controversial material. Wherever possible gaps in late 1990s knowledge has been indicated.

Full Product Details

Author:   T. Franklin ,  George Alan Snow ,  George Alan Snow
Publisher:   Chapman and Hall
Imprint:   Chapman and Hall
Edition:   Softcover reprint of the original 1st ed. 1998
Dimensions:   Width: 18.90cm , Height: 1.00cm , Length: 24.60cm
Weight:   0.362kg
ISBN:  

9780412821905

ISBN 10:   0412821907
Pages:   166
Publication Date:   29 March 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 The Development of Antimicrobial Agents Past, Present and Future.- 1.1 The social and economic importance of antimicrobial agents.- 1.2 An outline of the historical development of antimicrobial agents.- 1.3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds.- 1.4 Uncovering the molecular basis of antimicrobial action.- 1.5 Scope and layout of the present book.- 2 Vulnerable Shields — The Cell Walls of Bacteria and Fungi.- 2.1 Functions of the cell wall.- 2.2 Structure of the bacterial wall.- 2.3 Structure and biosynthesis of peptidoglycan.- 2.4 Antibiotics that inhibit peptidoglycan biosynthesis.- 2.5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria.- 2.6 The structure of the fungal cell wall.- 2.7 Inhibitors of the biosynthesis of the fungal cell wall.- 3 Antiseptics, Antibiotics and the Cell Membrane.- 3.1 Microbe killers: antiseptics and disinfectants.- 3.2 Polypeptide antibiotics.- 3.3 lonophoric antibiotics.- 3.4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols.- 4 Inhibitors of Nucleic Acid Synthesis.- 4.1 Compounds affecting the biosynthesis and utilization of nucleotide precursors.- 4.2 Inhibitors of nucleic acid biosynthesis at the polymerization stage.- 5 Inhibitors of Protein Biosynthesis.- 5.1 Ribosomes.- 5.2 Stages in protein biosynthesis.- 5.3 Puromycin.- 5.4 Inhibitors of aminoacyl-tRNA formation.- 5.5 Inhibitors of initiation and translation.- 5.6 Inhibitors of peptide bond formation and translocation.- 5.7 Nitrofurantoin — a ribosomal poison?.- 5.8 Effects of inhibitors of 70S ribosomes on eukaryotic cells.- 6 Antimicrobial Drugs with other Modes of Action.- 6.1 Antibacterial agents.- 6.2 A unique antifungal antibiotic — griseofulvin.- 6.3Antiviral agents.- 6.4 Antiprotozoal agents.- 7 Penetrating the Defences: How Antimicrobial Drugs Reach Their Targets.- 7.1 Cellular permeability barriers to drug penetration.- 7.2 Multidrug efflux in bacteria.- 7.3 Examples of the uptake of antibacterial drugs.- 7.4 Uptake of antimicrobial drugs by eukaryotic pathogens.- 8 The Genetic Basis of Resistance to Antimicrobial Drugs.- 8.1 Mutations and the origins of drug-resistance genes.- 8.2 Gene mobility and transfer in bacterial drug resistance.- 8.3 Global regulators of drug resistance in Gram-negative bacteria.- 9 Biochemical Mechanisms of Resistance to Antimicrobial Drugs.- 9.1 Enzymic inactivation of drugs.- 9.2 Modification of drug targets.- 9.3 Drug efflux pumps.- 9.4 Other mechanisms of resistance.- 9.5 Drug resistance and the future of chemotherapy.

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