Overview

Leading international researchers and clinicians review the latest findings on the cellular and molecular foundations of allergic diseases, particularly those of the airway, skin, and bowel. The key topics treated span the range from epidemiology and the mechanisms of inflammation, to signaling in pathogenesis and allergic reactions. Each contributor treats the pathophysiology of allergy in various organ-based diseases and syndromes, emphasizing important new findings from cellular and molecular biology that illuminate these diseases, but also reveal important leads for the development of novel drugs and therapeutic strategies. Its up-to-date, clinically relevant approach will establish the book as the new standard knowledge base - not only for specialists in clinical immunology and allergy, but also for internists seeking a deeper understanding of the allergic diseases they treat, for scientists studying the cellular and molecular biology of inflammation and immunity, and for researchers focused on drug discovery and therapeutics.

Full Product Details

Author:   Judah A. Denburg
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1998 ed.
Dimensions:   Width: 17.80cm , Height: 3.30cm , Length: 25.40cm
Weight:   3.060kg
ISBN:  

9780896034044

ISBN 10:   0896034046
Pages:   599
Publication Date:   04 August 1998
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

I. Epidemiology/IgE.- 1 Molecular Mechanisms of Isotype Switching to IgE.- 2 Cytokines and IgE Regulation.- 3 Environmental Allergens.- 4 Ontogeny of Allergy.- II. Inflammation: Cellular Aspects.- 5 The Role of the Bone Marrow in Allergic Disease.- 6 The Role of Mast Cells in Inflammation and Homeostatis.- 7 Human Langerhans Cells.- 8 Eosinophils.- 9 Role of Basophils in Allergic Reactions.- 10 Neurogenic Inflammation in Allergic Disease.- 11 Inflammation: Thl/Th2 Cells.- 12 T-Cells in the Pathogenesis of Asthma and Allergic Diseases.- 13 Role of CD8+ T-Cells in the Regulation of Immunoglobulin E.- 14 Airway Wall Structure.- 15 Epithelium.- III. Inflammation: Molecular Aspects.- 16 Proinflammatory Cytokines in Allergic Disease.- 17 Hemopoietic Cytokines: Function, Receptors, and Signal Transduction.- 18 Adhesion Receptors in Allergic Disease.- 19 Cell/Cytokine Interactions.- 20 Signaling in Mast Cells.- 21 Signaling in Human Basophils.- 22 Eosinophil Signal Transduction.- IV. Pathogenesis.- 23 Pathogenesis of Allergic Rhinitis.- 24 Pathogenic Mechanisms of Urticaria.- 25 Atopic Eczema.- 26 Pathogenesis of Asthma.- 27 Pathogenesis of Allergic Conjunctivitis.- V. Therapeutics.- 28 Glucocorticoids (Corticosteroids).- 29 Beta-Agonists.- 30 Sodium Cromoglycate and Nedocromil Sodium.- 31 Airway Remodeling and Repair.

Reviews

The book presents a broad overview of the field at a level that is easy to understand...provides an advanced understanding of the current state of the field and leaves the reader receptive to new concepts and therapies for allergic disease that will soon be forthcoming -Dale T. Umetsu, MD, PhD, review in the April 29, 1999 issue of The New England Journal of Medicine ...an excellent book on allergy and allergic diseases...a carefully thought-out whole, starting with IgE mechanisms, environmental allergens, and the new jungle hypothesis of atopic disorders beginning in early childhood. The book then proceeds to cellular and molecular aspects of inflammation, highlighting the key points of the pathogenesis of allergy in different organs, and ending with the essentials of treatment. - Allergy The book certainly has the five main features described in the presentation: it is written by leading authorities in allergy research...it provides an updated comprehensive survey of the mechanisms of allergic diseases; it illustrates the cellular and molecular bases of allergy and asthma; it emphasizes pathogenesis and the relevance of mechanisms to clinical expression; it includes useful information on therapeutics and possibilities for drug discovery. - EACCI

The book presents a broad overview of the field at a level that is easy to understand. . .provides an advanced understanding of the current state of the field and leaves the reader receptive to new concepts and therapies for allergic disease that will soon be forthcoming -Dale T. Umetsu, MD, PhD, review in the April 29, 1999 issue of The New England Journal of Medicine ...an excellent book on allergy and allergic diseases....a carefully thought-out whole, starting with IgE mechanisms, environmental allergens, and the new jungle hypothesis of atopic disorders beginning in early childhood. The book then proceeds to cellular and molecular aspects of inflammation, highlighting the key points of the pathogenesis of allergy in different organs, and ending with the essentials of treatment. - Allergy The book certainly has the five main features described in the presentation: it is written by leading authorities in allergy research...it provides an updated comprehensive survey of the mechanisms of allergic diseases; it illustrates the cellular and molecular bases of allergy and asthma; it emphasizes pathogenesis and the relevance of mechanisms to clinical expression; it includes useful information on therapeutics and possibilities for drug discovery. - EACCI

""The book presents a broad overview of the field at a level that is easy to understand. . .provides an advanced understanding of the current state of the field and leaves the reader receptive to new concepts and therapies for allergic disease that will soon be forthcoming""-Dale T. Umetsu, MD, PhD, review in the April 29, 1999 issue of The New England Journal of Medicine ""...an excellent book on allergy and allergic diseases....a carefully thought-out whole, starting with IgE mechanisms, environmental allergens, and the new ""jungle hypothesis"" of atopic disorders beginning in early childhood. The book then proceeds to cellular and molecular aspects of inflammation, highlighting the key points of the pathogenesis of allergy in different organs, and ending with the essentials of treatment."" - Allergy ""The book certainly has the five main features described in the presentation: it is written by leading authorities in allergy research...it provides an updated comprehensive survey of the mechanisms of allergic diseases; it illustrates the cellular and molecular bases of allergy and asthma; it emphasizes pathogenesis and the relevance of mechanisms to clinical expression; it includes useful information on therapeutics and possibilities for drug discovery."" - EACCI

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