Overview

Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity of chemicals and other agents. Permanent mutation in genes and chromosomes can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discussed in Advances in Mutagenesis Research are: 1. The understanding of the molecular mechanisms leading to mutations, and 2. the prevention of a thoughtless introduction of mutagenic agents into the environment.

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Author:   Y.F. Bogdanov ,  E. Dikomey ,  N.A. Liapunova ,  W.-U. Müller
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1994
Volume:   5
Dimensions:   Width: 15.50cm , Height: 1.10cm , Length: 23.50cm
Weight:   0.324kg
ISBN:  

9783642781957

ISBN 10:   3642781950
Pages:   193
Publication Date:   16 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Micronucleus Assays.- 1 Major Historical Events in Micronucleus Research.- 2 Characteristics, Origin, and Criteria of Micronuclei.- 3 Assay Systems and Methods for Detection of Micronuclei.- 4 Artifacts and Pitfalls.- 5 Characteristics of the Assay System Affecting Micronucleus Yield.- 6 Advantages and Disadvantages of Micronuclei as Assay System.- 7 Application of Micronuclei in Various Fields of Research.- 8 Future Aspects of Micronucleus Research.- References.- Mechanisms of Thermal Radiosensitization Studied in CHO Cells.- 1 Introduction.- 2 Effect of Heat on Radiosensitivity.- 3 DNA Damage.- 4 Effect of Heat on the Activity of Polymerase ß.- 5 Summary.- References.- Alexandra A. Prokofyeva-Belgovskaya (1903–1984) Her Life and Contribution to Cytogenetics.- 1 Bibliographical Notes.- 2 Studying Animal Chromosome Morphology.- 3 Collaboration with C.B. Bridges and H.J. Muller.- 4 Genes and Chromomeres.- 5 Studying Heterochromatic Regions of Drosophila Chromosomes.- 6 The Chromocenter and the X and Y Chromosomes.- 7 Discovery of Telomeric and Intercalary Heterochromatin.- 8 Discovery of High X-Ray Sensitivity of Heterochromatic Regions.- 9 Position Effect of the Variegated Type and the “Heterocyclicity Hypothesis”.- 10 Victim of Lysenko.- 11 Restitution.- 12 Human Chromosome Research.- 13 Family and Friends.- 14 The Leader of Cytogenetics in the USSR.- 15 Place in History.- References.

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