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Author:   J. Wayne Streilein ,  etc. ,  et al
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Volume:   vol 10
Dimensions:   Width: 28.00cm , Height: 1.20cm , Length: 21.50cm
Weight:   0.919kg
ISBN:  

9780199631841

ISBN 10:   0199631840
Pages:   274
Publication Date:   01 August 1990
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

Part 1 Antigen-specific receptors: mechanism and control of 1g heavy chain class-switching, Frederick W.Alt; origin and receptor diversity of epithelium associated cells, James P.Allison; control of T cell development by the T cell receptor for antigen, Harald Von Boechmer. Part 2 Diseases of abnormal antigen receptor formation: mechanism of DNA rearrangement in antigen receptor genes, Hitoshi Sakano; abnormal antigen receptor formation in normal, ataxiatelangiectasia, and malignant lymphocytes, Illan R.Kirsch; chromosomal translocations in T cells and developmentally regulated genes, Terence H.Rabbits. Part 3 Receptors, immunological structure and pharmaceutical development: structural studies of ligands and receptors, Mark I.Green; structure/function studies of human class I and class II histocompatability antigens, Don C.Wiley; the major receptor for human rhinovirus, Jeffrey M.Greve; biological properties of genetically engineered antigenic hybirds of polymers and the nature of a human polio virus receptor molecule, Eckard A.Wimmer. Part 4 The Feodor Lynen lecture: super antigens, their functions in health and disease, Phillippa Marrack; selection, tolerance and the T cell repertoire, John W.Kappler. Part 5 The distinguished service award: antibodies - a paradigm for the biology of molecular recognition, Cesar Milstein. Part 6 Molecular mechanisms in autoimmunity: immunoglobulin genes in grave's disease, Bonnie Blomberg; immunogetics of collagen induced and reactive arthritis, Chella S.David; molecular design of agents blocking interactions of T cells with self, Lawrence Steinman. Part 7 Manipulating the monoclonal: rapid cloning of antibody genes from small numbers of cells, James W.Larrick; engineering of antibodies produced in E. coli, Andreas G.Pluckthun; biotechnology and developing countries - Cuba's monoclonal antibody story; Jorge V. Gavilondo-Cowley. Part 8 Disordered regulation of lymphocyte activation: defects in assembly and transduction of human T cell receptors, Cox Terhorst; antisense RNA analyses in lymphocytes - defining new functions for cell surface molecules, Mark L.Tykocinski; new cytotoxic agents created by the fusion of toxin and cell recognition genes, Ira H.Pastan. Part 9 Manipulating the monoclonal: immunotoxins in lymphoma and AIDS, Ellen S. Vitetta; new strategies in biological catalyst design, Peter G.Schultz; constant region mutant and their influence on effector functions, Sherie L.Morrison; the use of bifunctional monoclonal antibodies in diagnosis and therapy, Christopher L.Reading. Part 10 Antigen recognition and lymphocyte activation: molecular basis of immune recognition, Jack L. Strominger; a transgenic model of T cell development, Denis Y.Loh. Part 11 Genetic disorder of surface molecules: genetic control of regulation and disregulation of HLA class II genes, Bernard F. Mach (Part contents).

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