Overview

Volume 68 of Advances in Cancer Research continues the tradition of publishing up-to-date reviews and hot topics in cancer research. This volume begins with a Foundations in Cancer Research article by Harald zur Hausen that reviews his years of research on the idea that cancer can be triggered by infection. The structure and function of the cytokine receptor superfamily and its association with leukemias are discussed in depth by James Ihle. Marcia Hall and Gordon Peters review the evidence indicating that genetic abnormalities hinder the function of certain cyclins and their inhibitors. The most widely studied protooncogene, c-myc, is reviewed by Marie Henriksson and Bernhard Luscher; the chapter focuses on the function of c-myc as a transcription factor rather than on the effects of gene translocation and activation on malignancies. Ham Werner and Derek LeRoith present data on the role that insulin-like growth factors play on cell growth and regulation. In the final chapter, Olli-P. Kallioniemi and Tapio Visakorpi investigate the field of prostate cancer and, more importantly, the biological reason and natural history behind the growth of this cancer.

Full Product Details

Author:   George F. Vande Woude ,  G. Klein ,  George F. Vande Woude (NCI Frederick Cancer Research and Development Center, Maryland, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.845kg
ISBN:  

9780120066575

ISBN 10:   0120066572
Pages:   484
Publication Date:   01 January 1991
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

myc-Family oncogenes in the development of normal and neoplastic cells, R.A. DePinho, et al; transcriptional and transforming activities of the adenovirus E1A proteins, T. Schenk and J. Flint mitogenic action of (Lyso)-phosphatidic acid, W.H. Moolenaar; expression and interaction of the SRC family tyrosine protein kinases in T lymphocytes, J.B. Bolen, et al; implication the bcr/abl gene in the pathogenesis of Philadelphia chromosome-positive human leukemia, G.Q. Daley and Y. Ben-Neriah; oncoprotein kinases in Mitosis, D. Shalloway and S. Shenoy; current status of the BCR gene and its involvement with human leukemia, M.L. Campbell and R.B. Arlinghaus; p53 and human malignancies, V. Rotter and M. Prokocimer; directed plasminogen activation of the surface of normal and malignant cells, J. Pollanen, et al; Epstein Barr virus associated lymphoproliferative disorders in immunocompromised individuals, J.A. Thomas, et al; ADF, a growth-promoting factor derived from adult T-cell leukemia and homologous to thioredoxin - involvement in lymphocyte immortalization by HTLV-1 and EBV, J. Yodoi and T. Tursz; the hunt for endogenous growth inhibitor and/or tumour suppressing factors - their role in physiological and pathological growth regulation, O.H. Iversen.

Reviews

This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences. --AMERICAN SCIENTIST Excellent, highly informative, in-depth reviews... expertly written, up-to-date, and well-referenced. --JOURNAL OF MEDICINAL CHEMISTRY

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