Overview

This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience - the intersection between the discoveries that the adult brain makes new neurons and that it contains stem cells. The book begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumours, and dementias. This readable, single-authored volume is a unique resource for graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research.

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9780195179712

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Reviews

Since most neurons of the human brain last throughout the life span, the discovery that in selected regions of the mammalian brain neurons can be produced during adulthood has fascinated both scientists and the general public. Because of the interesting conceptual and potential medical significance, more than the usual number of irreproducible claims and irresponsible promises have been made. This impressive monograph by Gerd Kempermann, a scientist who has devoted his entire research career to this important subject, is a must for those who seek a balance between hype and reality. The text is written with a keen sense of history and attention to details. It should be read by both specialists and the educated public. Pasko Rakic, Yale University

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