Overview

Michael Williams' comprehensive new survey volume of Adenosine and Adenosine Receptors highlights the phenomenal progress made during the last decade in understanding the roles of adenosine and related purines in tissue function. It also focuses on receptor subtypes and the search for selective ligands and the development of radioligand binding assays that were instrumental in advancing research in this important area. Since adenosine was first found to be a potent hypotensive agent 60 years ago, many pharmaceutical companies have exhibited great interest in designing new adenosine receptor ligands, as well as agonists and antagonists, specifically aimed at developing promising new drugs. In addition, adenosine and purinergic systems have since been found to be integrally involved in the function of virtually every body system. Leading experts in the field have contributed a wealth of information here, and the book's chapters include coverage of: historical perspectives radioligand binding assays signal transduction mechanisms electrophysiological aspects structure activity relationships of adenosine A1 and A2 receptors adenosine release markers of adenosine metabolism and transport in central purinergic systems adenosine in cardiovascular, renal, respiratory, and CNS function adenosine and host defense modulation future trends. Adenosine and Adenosine Receptors is an indispensable resource for everyone involved in receptor research, pharmacology, biochemistry, and related fields.

Full Product Details

Author:   Michael Williams
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1990 ed.
Dimensions:   Width: 15.20cm , Height: 2.80cm , Length: 22.90cm
Weight:   0.918kg
ISBN:  

9780896031630

ISBN 10:   0896031632
Pages:   516
Publication Date:   11 June 1990
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Section I: Historical Perspective.- 1 Adenosine Receptors: An Historical Perspective.- Section 2: Characterization of the Receptor and Its Binding Site.- 2 Radioligand Binding Assays for Adenosine Receptors.- 3 Structure-Activity Relationships of Adenosine A1 and A2 Receptors.- Section 3: Biochemical Mechanisms of Receptor Action.- 4 Signal Transduction Mechanisms for Adenosine.- 5 Electrophysiological Aspects of Adenosine Receptor Function.- 6 Adenosine Release.- 7 Adenosine Deaminase and [3H]Nitrobenzylthionosine as Markers of Adenosine Metabolism and Transport in Central Purinergic Systems.- Section 4: Physiological Functions of Adenosine Receptors.- 8 Adenosine and Cardiovascular Function.- 9 Adenosine and Renal Function.- 10 The Role of Adenosine in Respiratory Physiology.- 11 Adenosine in Central Nervous System Function.- Section 5: Receptor Regulation.- 12 Adenosine and Host Defense: Modulation Through Metabolism and Receptor-Mediated Mechanisms.- Section 6: Future Vistas.- 13 Adenosine Receptors: Future Vistas.

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