Acids and Bases: Solvent Effects on Acid-Base Strength

Author:   Brian G. Cox (Pharmaceutical Development, AstraZeneca R&D)
Publisher:   Oxford University Press
ISBN:  

9780199670512


Pages:   156
Publication Date:   31 January 2013
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Acids and Bases: Solvent Effects on Acid-Base Strength


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Full Product Details

Author:   Brian G. Cox (Pharmaceutical Development, AstraZeneca R&D)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 20.00cm , Height: 1.40cm , Length: 24.70cm
Weight:   0.528kg
ISBN:  

9780199670512


ISBN 10:   019967051
Pages:   156
Publication Date:   31 January 2013
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1: Introduction 2: Acid-base equilibria: quantitative treatment 3: Solvation and acid-base strength 4: Determination of dissociation constants 5: Protic solvents 6: High-basicity, aprotic solvents 7: Low-basicity and low-polarity aprotic solvents 8: Acid-base equilibria and salt formation 9: Appendices: Dissociation constants in methanol and aprotic solvents Index

Reviews

Acid-base equilibria are one of the most important chemical reactions - affecting living systems through to industrial processes. This book covers everything any scientist would like to know about this topic from structural and solvent effects to the practical determination of dissociation constants. Cox follows his mentor R.P. Bell in presenting a lucid and well-written comprehensive text. Highly recommended. * Michael Page, University of Huddersfield * Acidbase equilibria are intimately coupled to many of the processes involved in synthetic and analytical chemistry, including reaction rates and selectivity, solubility and partition equilibria, catalytic cycles and chromatographic retention times. These equilibria are extraordinarily sensitive to the nature of the solvent, with some equilibrium constants changing by as much as 1010 on transfer from water to aprotic solvents. This book, by a practitioner with a lifetimes experience in the area, dissects a complex subject and provides a clear discussion of the several interacting factors that determine ionisation behaviour. It will be an invaluable resource to scientists involved with chemistry in non-aqueous solvents. * John Atherton, University of Huddersfield *


Acidbase equilibria are intimately coupled to many of the processes involved in synthetic and analytical chemistry, including reaction rates and selectivity, solubility and partition equilibria, catalytic cycles and chromatographic retention times. These equilibria are extraordinarily sensitive to the nature of the solvent, with some equilibrium constants changing by as much as 1010 on transfer from water to aprotic solvents. This book, by a practitioner with a lifetimes experience in the area, dissects a complex subject and provides a clear discussion of the several interacting factors that determine ionisation behaviour. It will be an invaluable resource to scientists involved with chemistry in non-aqueous solvents. * John Atherton, University of Huddersfield * Acid-base equilibria are one of the most important chemical reactions - affecting living systems through to industrial processes. This book covers everything any scientist would like to know about this topic from structural and solvent effects to the practical determination of dissociation constants. Cox follows his mentor R.P. Bell in presenting a lucid and well-written comprehensive text. Highly recommended. * Michael Page, University of Huddersfield *


Acidbase equilibria are intimately coupled to many of the processes involved in synthetic and analytical chemistry, including reaction rates and selectivity, solubility and partition equilibria, catalytic cycles and chromatographic retention times. These equilibria are extraordinarily sensitive to the nature of the solvent, with some equilibrium constants changing by as much as 1010 on transfer from water to aprotic solvents. This book, by a practitioner with a lifetimes experience in the area, dissects a complex subject and provides a clear discussion of the several interacting factors that determine ionisation behaviour. It will be an invaluable resource to scientists involved with chemistry in non-aqueous solvents. John Atherton, University of Huddersfield Acid-base equilibria are one of the most important chemical reactions - affecting living systems through to industrial processes. This book covers everything any scientist would like to know about this topic from structural and solvent effects to the practical determination of dissociation constants. Cox follows his mentor R.P. Bell in presenting a lucid and well-written comprehensive text. Highly recommended. Michael Page, University of Huddersfield


Author Information

Dr Brian G. Cox was educated at the University of Melbourne, followed by academic research or teaching posts at the Australian National University, the University of Stirling, Cornell University, and the Max-Planck Institut für biophys. Chemie, Göttingen. He subsequently held industrial positions of Corporate Research Associate with ICI and Syngenta, and Associate Principal Scientist and Consultant with AstraZeneca. In addition, he has held Visiting Professorships at the Universities of Surrey, St Andrews, Bologna, and Chieti, and University College, Dublin, and most recently acted as Senior Advisor in Chemistry at the Institute of Chemical and Engineering Science in Singapore.

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