Overview

Edited by a stellar team of scientists compiling more than 120 papers into a single volume, the XIth Annual International Symposium on Amyloidosis represents the most important review of the state-of-the-science and future directions of this rapidly growing field. An unparalleled cast of pioneering researchers, including keynote speaker and Nobel Laureate Dr. Stanley Prusiner, present groundbreaking research in systemic amyloidosis including the mechanisms of disease and cellular toxicity, AA amyloidosis, familial amyloidosis, AL amyloidosis, clinical trials, and emerging Divided into six sections, the book begins with a study of the mechanisms of fibril formation and cellular response. It investigates possible horizontal transmission, charge differences of deposits in AL and NALCDD, and novel assays to detect amyloid induced apoptosis. The second section considers AA and localized amyloidosis and presents advances in non-invasive imaging, amyloid typing, and the translocation of systemic amyloidosis. The section on familial and TTR amyloidosis features an original report on hereditary gelsolin amyloidosis in an Iranian family, as well as other novel and rare mutations. An extensive section on AL amyloidosis introduces ALBASE as a platform analysis tool, AL amyloidosis in the elderly, and a study of the therapeutic potential of naturally occurring antibodies. Section five focuses on new and emerging diagnostic and translational approaches including characterization and identification through biopsy, mass spectrometry, proteomics, and the use of an amyloid ""chip"". The book concludes with clinical trials of diflunisal and high dose melphalan-dexamethasone and autologous stem cell transplantation. translational approaches. Focusing on new basic and translational medicine approaches in systemic amyloidosis, XIth Annual International Symposium on Amyloidosis provides clinicians and researchers with an invaluable single source reference to the most up-to-date research in the field.

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9781420042818

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Martha Skinner, John L. Berk, Lawreen H. Connors, David C. Seldin

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