Overview

Von Hippel-Lindau (VHL) disease is an inherited disorder characterized by the abnormal growth of both benign and cancerous tumors and cysts in many parts of the body. Considering the number of manifestations of the VHL disease, screening and management is complex and requires a multidisciplinary effort as well as an understanding of the interplay between all the manifestations. This book is one of the first to provide fundamental knowledge about VHL and the know-how on the various manifestations of this complex syndrome. Various aspects of VHL are reflected in this book's table of contents, written by the leading experts in each field discussed. Comprehensive and easy-to-use, this book offers a detailed and comprehensive analysis of the manifestations and management of patients with VHL and serves as the definitive book on the management of patients with VHL for surgical oncologists, endocrinologists, urologists, neurosurgeons, ophthalmologist, radiologists, and all primary care physicians.

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9783031538575

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Dhaval Patel, MD, FACSDhaval Patel MD, FACS is a board-certified general surgeon and endocrine surgeon who has worked extensively with patients with VHL at the National Institutes of Health (NIH). At the NIH, he helped follow and manage over 300 patients with VHL-associated pancreatic neuroendocrine tumors. He has written and been co-author on multiple articles related to VHL and has performed basic and clinical research related to VHL. He is currently an Assistant Professor of Surgery at the Hackensack Meridian School of Medicine and has published in top tier journals such as the New England Journal of Medicine, JAMA Oncology, Annals of Surgery, and Clinical Cancer Research. Amit Tirosh, MDAmit Tirosh MD is the head of the VHL Clinical Care Center and Endocrine Neoplasia Translational Research Center (ENTIRE) at Sheba Medical Center, Tel HaShomer, Israel, and led the Guidelines Development subcommitteefor VHL-related pancreatic manifestations, and a member of the clinical council of the VHL Alliance. Dr Tirosh established the Israeli VHL Clinical Care Center (VHL CCC), one of the few VHL CCC outside the United States. Dr Tirosh studies the pancreatic manifestatios in patients with VHL, and his studies have been published in high-tier journals, including JAMA Oncology, Cancer, Radiology, Journal of Clinical Endocrinology and Metabolism and many more. His scientific focus is developing novel models for pseudohypoxic neuroendocrine tumors, and identification of non-genetic proneoplastic drivers in VHL-deficient tumors.

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