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Author:   Dhaval Thakor Patel ,  Amit Tirosh
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2024
ISBN:  

9783031538575

ISBN 10:   3031538579
Pages:   252
Publication Date:   06 April 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Dr. Von Hippel, Dr. Lindau and the History of VHL Disease.- VHL Gene and the Molecular Pathophysiology of VHL.- Epidemiology of the VHL Disease.- Hemangioblastomas of Brain and Spine.- Retinal Hemangioblastomas.- Clear-cell Renal Cell Carcinoma.- Endolymphatic Sac Tumors.- Pheochromocytomas.- Pancreatic Manifestations of VHL.- Anatomical and Functional Imaging in VHL.- Advanced Disease-Medical Interventions.- Current Clinical Trials, and Future Research Perspectives.- Suggested Guidelines for the Screening, Surveillance and Management of VHL Manifestations.- Psychological Aspects of VHL.

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Author Information

Dhaval Patel, MD, FACSDhaval Patel MD, FACS is a board-certified general surgeon and endocrine surgeon who has worked extensively with patients with VHL at the National Institutes of Health (NIH). At the NIH, he helped follow and manage over 300 patients with VHL-associated pancreatic neuroendocrine tumors. He has written and been co-author on multiple articles related to VHL and has performed basic and clinical research related to VHL. He is currently an Assistant Professor of Surgery at the Hackensack Meridian School of Medicine and has published in top tier journals such as the New England Journal of Medicine, JAMA Oncology, Annals of Surgery, and Clinical Cancer Research. Amit Tirosh, MDAmit Tirosh MD is the head of the VHL Clinical Care Center and Endocrine Neoplasia Translational Research Center (ENTIRE) at Sheba Medical Center, Tel HaShomer, Israel, and led the Guidelines Development subcommitteefor VHL-related pancreatic manifestations, and a member of the clinical council of the VHL Alliance. Dr Tirosh established the Israeli VHL Clinical Care Center (VHL CCC), one of the few VHL CCC outside the United States. Dr Tirosh studies the pancreatic manifestatios in patients with VHL, and his studies have been published in high-tier journals, including JAMA Oncology, Cancer, Radiology, Journal of Clinical Endocrinology and Metabolism and many more. His scientific focus is developing novel models for pseudohypoxic neuroendocrine tumors, and identification of non-genetic proneoplastic drivers in VHL-deficient tumors.

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