Overview

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing.  Finally, the book also provides an overview of the updated research on calciumchannel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

Full Product Details

Author:   Gerald Werner Zamponi ,  Norbert Weiss
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2022
Weight:   1.348kg
ISBN:  

9783031088834

ISBN 10:   3031088832
Pages:   710
Publication Date:   10 November 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface: History of VGCCs                                                                                           STRUCTURAL AND MOLECULAR ASPECTS OF VGCCS 1.       Measuring and manipulating calcium 2.       Structure, function and subunit assembly of VGCC 3.       Splice variation and RNA editing of VGCCs 4.       Mechanisms of calcium channel permeation 5.       Regulation by beta subunits        6.       Regulation by alpha2 delta subunits 7.       VGCCs in invertebrates REGULATION OF VGCCS 8.       Modulation by GPCRs and second messengers 9.       Trafficking of VGCCs 10.   Calcium regulation 11.   Calcium channel complexes with other channels 12.   Regulation of gene transcription by VGCCs  (PATHO)PHYSIOLOGY OF VGCCS 13.   Lessons from knock-out and knock-in mice 14.   VGCCs and synaptic transmission 15.   Cardiovascular syste 16.   Calcium channels and exocytosis in chromaffin cells 17.   Calcium channels in the pancreas in health and disease 18.   Skeletal muscle system 19.   Auditory and visual systems 20.   Calcium channels and pain transmission 21.   Migraine 22.   Epilepsy 23.   Psychiatric disorders 24.   Parkinson’s disease 25.   Reproductive system 26.   Cancer PHARMACOLOGY OF VGCCS 27.   Molecular determinants of VGCC pharmacology 28.   Interactions with peptide toxins 29.   Clinical pharmacology and drug discovery

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Author Information

Dr. Gerald Werner Zamponi is a Professor in the Department of Physiology and Biophysics, and Canada Research Chair in Molecular Neuroscience, at the University of Calgary, Calgary, Canada.   Dr. Norbert Weiss is an Assistant Professor in the Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

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